Abstract: Highperfomance liquid chromatography was used to study how to control solasedine hydrochloride quality. Column was Agilent ZORBAX Eclipse XDB-C₁₈ column (150 mm×4.6 mm, 5 μm), mobile phase was V_methanol∶V_acetonitrile∶V_{0.020 mol·L^-1lammonium acetate}=60 ∶35 ∶5, flow rate was 1 mL/min, detection wavelength 205 nm, injection volume 10 μL, the solasodine hydrochloride quality separated from other impurities in a good linear range of 5~500 μg/mL (r=0.999 3), numder of theoretical plates n＞12 000(R>1.5); the average recovery for the sample 98.6% (n=9). Relative standard deviation of reproducibility (RSD) was 0618%.

Key words: HPLC, solasedine hydrochloride, identification, quality control