中药双黄补联合西帕依固龈液对种植体周围炎患者牙周炎症的改善作用及其临床意义

doi:10.13481/j.1671-587x.20170629

吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (06): 1226-1230.doi: 10.13481/j.1671-587x.20170629

中药双黄补联合西帕依固龈液对种植体周围炎患者牙周炎症的改善作用及其临床意义

陈飞¹, 焦鹏¹, 车鸿泽¹, 金权¹, 许丽硕¹, 张莉², 马宁¹

1. 吉林大学口腔医院牙周病科, 吉林长春 130021;
2. 吉林大学口腔医院急诊科, 吉林长春 130021

收稿日期:2017-07-25 出版日期:2017-11-28 发布日期:2017-12-01
通讯作者: 马宁,教授,硕士研究生导师(Tel:0431-88796039,E-mail:maningbsh76@sina.com);张莉,副教授,硕士研究生导师(Tel:0431-85579359,E-mail:zlamy1009@sina.com) E-mail:maningbsh76@sina.com;zlamy1009@sina.com
作者简介:陈飞(1988-),男,福建省莆田市人,在读医学硕士,主要从事牙周病诊治方面的研究。
基金资助:
吉林省中医药管理局科研项目资助课题（2016080）

Improvement effect of Shuanghuangbu combined with Xipayi Mouth Rinse on periodontal inflammation of peri-implantitis patients and its clinical significance

CHEN Fei¹, JIAO Peng¹, CHE Hongze¹, JIN Quan¹, XU Lishuo¹, ZHANG Li², MA Ning¹

1. Department of Periodontics, Stomatology Hospital, Jilin University, Changchun 130021, China;
2. Department of Emergency, Stomatology Hospital, Jilin University, Changchun 130021, China

Received:2017-07-25 Online:2017-11-28 Published:2017-12-01

摘要/Abstract

摘要： 目的：研究中药双黄补联合西帕依固龈液对种植体周围炎患者牙周指数的影响，探讨中药双黄补联合西帕依固龈液治疗种植体周围炎的疗效。方法：将40例种植体周围炎患者随机分为对照组和中药组（n=20）。在对种植体进行龈上洁治、龈下刮治后，中药组患者采用西帕依固龈液冲洗种植周袋，同时以精细探针顺种植周袋壁缓慢插入至袋底，留置中药双黄补，缓慢后退探针使药物溢出至牙龈边缘；对照组患者采用3%双氧水、0.9%氯化钠注射液交替冲洗牙周袋，观察2组患者种植体治疗前后改良菌斑指数（mPLI）、牙周袋深度（PPD）和改良龈沟出血指数（mSBI）。采用Whatman1号滤纸条吸取治疗前后种植体周龈沟液（PISF），检测2组患者PISF质量；采用ELISA法检测PISF中炎症因子白细胞介素1β（IL-1β）水平。结果：治疗前2组患者年龄构成、性别比例、受试牙位牙周指数、PISF质量和PISF中IL-1β水平比较差异无统计学意义（P>0.05）。经不同治疗措施干预后，2组种植体周围炎患者牙周指数（PPD、mSBI和mPLI）、PISF质量以及PISF中IL-1β水平比较差异有统计学意义（P < 0.05）。治疗后，与对照组比较，中药组患者mSBI、mPLI、PISF质量和PISF中IL-1β水平比较差异有统计学意义（P < 0.05）；中药组患者PPD低于对照组，但组间比较差异无统计学意义（P > 0.05）。结论：中药双黄补联合西帕依固龈液治疗种植体周围炎的疗效显著，可改善患者牙周指数，降低患者PISF中IL-1β水平。

关键词: 双黄补, 改良菌斑指数, 改良龈沟出血指数, 西帕依, 种植体周围炎

Abstract: Objective:To investigate the effect of Chinese traditional medicine-Shuanghuangbu combined with Xipayi Mouth Rinse on the periodontal indexes of the peri-implantitis patients,and to detect the curative effect of Shuanghuangbu combined with Xipayi Mouth Rinse in the treatment of peri-implantitis. Methods:A total of 40 patients diagnosed as peri-implantitis were randomly divided into control group and Chinese traditional medicine group(n=20).All of the patients received supragingival scaling and subgingival scaling, and then the peri-implant pocket of the patients in Chinese traditional medicine group were washed with Xipayi Mouth Rinse, while the fine probe slided slowly along the inner wall of peri-implant pocket into the bottom and retained the Shuanghuangbu,and retreated gently and made the medicine overflow the gingival margin.The patients in control group were given 3% hydrogen peroxide and 0.9% sodium chloride injection washed by turns. The indexes of covering modified plaque index(mPLI), probing pocket depth (PPD),modified sulcular bleeding index(mSBI) of the patients in two groups at baseline and after treatment were detected; Whatman#1 was applied to aspirate the peri-implant sulcus fluid (PISF)which were weighed at baseline and after treatment,and the level of interleukin-1β(IL-1β) in PISF was analyzed by ELISA method. Results:No differences were observed in age,sex,periodontal indexes, weights of PISF and IL-1β levels of the patients in two groups before treatment (P>0.05). Compared with before treatment,the indexes including PPD, mSBI,mPLI,weight of PISF and IL-1β level in PISF of the patients in two groups were decreased after treatment(P < 0.05).After treatment, the differences in mSBI, mPLI, weight of PISF and IL-1β level in PISF of the patients between control group and Chinese traditional medicine group were significant(P < 0.05).Compared with control group,the PPD level of the patients in Chinese traditional medicine group was decreased,but the difference was not significant(P > 0.05). Conclusion:The curative effect of Chinese traditional medicine-Shuanghuangbu combined with Xipayi Mouth Rinse is obsious,and the treatment can improve the periodontal status and reduce the level of IL-1β in PISF.

Key words: modified sulcus bleding index, peri-implantitis, Shuanghuangbu, modified plaque index, Xipayi Mouth Rinse

中图分类号:

R781.41

陈飞, 焦鹏, 车鸿泽, 金权, 许丽硕, 张莉, 马宁. 中药双黄补联合西帕依固龈液对种植体周围炎患者牙周炎症的改善作用及其临床意义[J]. 吉林大学学报(医学版), 2017, 43(06): 1226-1230.

CHEN Fei, JIAO Peng, CHE Hongze, JIN Quan, XU Lishuo, ZHANG Li, MA Ning. Improvement effect of Shuanghuangbu combined with Xipayi Mouth Rinse on periodontal inflammation of peri-implantitis patients and its clinical significance[J]. Journal of Jilin University Medicine Edition, 2017, 43(06): 1226-1230.

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中药双黄补联合西帕依固龈液对种植体周围炎患者牙周炎症的改善作用及其临床意义

Improvement effect of Shuanghuangbu combined with Xipayi Mouth Rinse on periodontal inflammation of peri-implantitis patients and its clinical significance

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