人血浆抗谷胶蛋白抗体与不同年龄段精神分裂症患者发病的关联性

doi:10.13481/j.1671-587x.20180626

吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (06): 1263-1268.doi: 10.13481/j.1671-587x.20180626

人血浆抗谷胶蛋白抗体与不同年龄段精神分裂症患者发病的关联性

王嘉欣¹, 武宁², 金顺子³, 王彦君¹, 张萱¹

1. 吉林大学第二医院内分泌科, 吉林长春 130041;
2. 吉林大学中日联谊医院放疗科, 吉林长春 130033;
3. 吉林大学公共卫生学院卫生部放射生物学重点实验室, 吉林长春 130021

收稿日期:2018-03-21 出版日期:2018-11-28 发布日期:2018-11-28
通讯作者: 张萱,教授,博士研究生导师(Tel:0431-81136862,E-mail:jdeyzhangxuan@163.com) E-mail:jdeyzhangxuan@163.com
作者简介:王嘉欣(1985-),女,吉林省长春市人,主治医师,医学博士,在读医学博士后,主要从事人类重大疾病发病学方面的研究。
基金资助:
吉林省科技厅优秀青年人才基金资助课题（20170520022JH）；吉林省卫计委青年科技骨干培养计划项目资助课题（2016Q029）

Associations between human plasma anti-gliadin antibodies and occurrence of schizophrenia in patients with different ages

WANG Jiaxin¹, WU Ning², JIN Shunzi³, WANG Yanjun¹, ZHANG Xuan¹

1. Department of Endocrinology, Second Hospital, Jilin University, Changchun 130041, China;
2. Department of Radiotherapy, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
3. Key Laboratory of Radiobiology Research, Ministry of Health, School of Public Health, Jilin University, Changchun 130021, China

Received:2018-03-21 Online:2018-11-28 Published:2018-11-28

摘要/Abstract

摘要： 目的：探讨人血浆抗谷胶蛋白IgA和IgG抗体水平与不同年龄段中国北方汉族精神分裂症患者发病的关系，阐明人血浆谷胶蛋白抗体在精神分裂症发病中的作用。方法：收集313例中国北方汉族精神分裂症患者（精神分裂症组）和408名健康对照者（健康对照组）的血浆，采用酶联免疫吸附试验（ELISA）法检测各组研究对象人血浆抗谷胶蛋白IgA和IgG抗体水平。采用Pearson's相关分析和Mann-Whitney U检验比较精神分裂症组和健康对照组不同年龄段研究对象人血浆抗谷胶蛋白IgA及IgG抗体水平，并进行受试者工作特征（ROC）曲线分析。结果：研究对象人血浆抗谷胶蛋白IgA抗体水平与年龄和年龄分段呈正相关关系（r=0.177，P<0.01；r=0.171，P<0.01），人血浆抗谷胶蛋白IgG抗体水平与年龄和年龄分段呈负相关关系（r=-0.104，P<0.01；r=-0.127，P<0.01）。与健康对照组比较，精神分裂症组20~30岁年龄段和50~60岁年龄段患者人血浆抗谷胶蛋白IgA抗体水平升高（Z=-3.746，P<0.01；Z=-2.186，P=0.029）。与健康对照组比较，精神分裂症组20~30岁患者人血浆抗谷胶蛋白IgG抗体水平升高，但组间比较差异无统计学意义（P>0.05）。ROC曲线分析人血浆抗谷胶蛋白IgA和IgG抗体ROC曲线下面积（AUC）分别为0.573（SE=0.022，95% CI：0.53~0.62）和0.520（SE=0.022，95% CI：0.48~0.56），在特异度为92.2%的情况下灵敏度分别为13.7%和12.8%。结论：人血浆抗谷胶蛋白抗体水平升高与不同年龄段精神分裂症患者的发病有密切关联，人血浆抗谷胶蛋白抗体在精神分裂症年轻亚组患者中可能发挥重要作用。

关键词: 精神分裂症, 谷胶蛋白, 抗谷胶蛋白IgA抗体, 抗谷胶蛋白IgG抗体, 酶联免疫吸附试验

Abstract: Objective: To investigate the associations between the levels of human plasma anti-gliadin antibodies and occurrence of schizophrenia in the patients with different ages in Chinese Han population,and to clarify the effects of human plasma anti-gliadin antibodies in the occurrence of schizophrenia.Methods: The plasma samples were collected from 313 schizophrenia patients (schizophrenia group) and 408 healthy controls (healthy control group) in Chinese Han population. The levels of human anti-gliadin IgA and IgG antibodies of the subjects in various groups were detected by enzyme-linked immnosorbent assay(ELISA) method. The levels of human plasma anti-gliadin IgA and IgG antibodies in the subjects in schizophrenia group and healthy control group were analyzed by Pearson's correlation analysis and compared by Mann-Whitney U test; receiver operating characteristic (ROC) curve analysis was performed.Results: The level of plasma anti-gliadin IgA antibody showed a significantly positive correlation with the age and age ranges of the subjects(r=0.177,P<0.01;r=0.171,P<0.01); the level of plasma anti-gliadin IgG antibody showed significantly negative correlation with the age and age ranges of the subjects (r=-0.104, P<0.01;r=-0.127, P<0.01).Compared with healthy control group, the levels of plasma anti-gliadin IgA antibodies of the patients aged 20-30 years old and 50-60 years old in schizophrenia group were increased(Z=-3.746,P<0.01;Z=-2.186,P<0.05). Compared with healthy control group, the level of plasma anti-gliadin IgG antibody of the patients aged 20-30 years old in schizophrenia group was increased, but the difference was not statistically significant(P>0.05). The ROC curve analysis results showed that the area under ROC curve(AUC) of anti-gliadin IgA and IgG antibodies were 0.573 (SE=0.022, 95%CI:0.53-0.62) and 0.520 (SE=0.022, 95%CI:0.48-0.56). The sensitivities of anti-gliadin IgA and IgG antibodies were 13.7% and 12.8% when the specificity was 92.2%.Conclusion: The increasing of plasma anti-gliadin antibodies level is associated with the occurrence of schizophrenia in the patients with different age ranges in Chinese Han population, and the human plasma anti-gliadin antibodies maybe play an important role in the young schizophrenia patients.

Key words: schizophrenia, gliadin, anti-gliadin IgA antibody, anti-gliadin IgG antibody, enzyme-linked immunosorbent assay

中图分类号:

王嘉欣, 武宁, 金顺子, 王彦君, 张萱. 人血浆抗谷胶蛋白抗体与不同年龄段精神分裂症患者发病的关联性[J]. 吉林大学学报(医学版), 2018, 44(06): 1263-1268.

WANG Jiaxin, WU Ning, JIN Shunzi, WANG Yanjun, ZHANG Xuan. Associations between human plasma anti-gliadin antibodies and occurrence of schizophrenia in patients with different ages[J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1263-1268.

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人血浆抗谷胶蛋白抗体与不同年龄段精神分裂症患者发病的关联性

Associations between human plasma anti-gliadin antibodies and occurrence of schizophrenia in patients with different ages

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