关键词: 药理学, 炎症, 药物疗法

Abstract: Objective To investigate the preliminary effect of oxymatrine　(OMT) on inflammation and its mechanism. Methods Fifty mice were randomly divided into 5 groups: normal saline group, dexamethasone group and OMT groups with different doses (70,140,and 210 mg·kg^-1). The extent of ear swelling was observed in inflammation model caused by dimethyl benzene in mice. Forty-eight Wistar rats were randomly divided into 6 groups:normal saline group, dexamethasone group and OMT groups with different doses (50，100,and 150 mg·kg^-1),L-NAME+OMT 100 mg·kg^-1 group. Paw edema volume induced by dextran were observed in rats. Results The extents of ear swelling were decreased in dose-dependent manner after intraperitoneal injection of OMT 140 and 210 mg·kg^-1 in mice compared with control (P<0.05 or P<0.01). Paw edema volumes were reduced after intraperitoneal injection of OMT 100 and 150 mg·kg^-1 in rats compared with control (P<0.05). L-NAME enhanced the effect of anti-inflammation of OMT. Conclusion OMT can reduce the extent of ear swelling induced by dimethylbenzene in mice and the paw edema volume caused by dextran in rats.Its anti-inflammatory effect may be not fully mediated by NO-cGMP pathway.

Key words: pharmacology, inflammation, drug therapy