化疗联合斑蝥酸钠维生素B6注射液对非小细胞肺癌患者的治疗效果及其机制

doi:10.13481/j.1671-587x.20180630

摘要/Abstract

摘要： 目的：探讨化疗联合斑蝥酸钠维生素B6注射液治疗非小细胞肺癌（NSCLC）患者的效果及其对患者生存质量的影响，并阐明其作用机制。方法：110例NSCLC患者根据采用的治疗方法不同分为化疗组（55例，采用单纯化疗）和联合组（55例，采用化疗联合斑蝥酸钠维生素B6注射液治疗）。比较2组患者的治疗有效率，治疗前后采用欧洲癌症研究与治疗组织肺癌生存质量（EORTC QLO-C43）量表对患者的生存质量进行评分，采用双抗体夹心酶联免疫吸附法检测患者血清中血管内皮细胞生长因子（VEGF）、肿瘤坏死因子α（TNF-α）和白细胞介素12（IL-12）水平。结果：联合组患者治疗后总有效率高于化疗组，但组间比较差异无统计学意义（χ²=0.806，P=0.369）。治疗前联合组和化疗组患者功能性量表、总体健康状况、症状子量表、肺癌特异性子量表评分比较差异无统计学意义（P>0.05）；治疗后联合组患者功能性量表和总体健康状况评分明显高于化疗组（P<0.05），症状子量表和肺癌特异性子量表评分明显低于化疗组（P<0.05）。治疗前联合组和化疗组患者血清中VEGF、TNF-α和IL-12水平比较差异无统计学意义（P>0.05）；治疗后联合组患者血清中VEGF水平明显低于化疗组（t=3.608，P<0.05），TNF-α和IL-12水平明显高于化疗组（t=3.426，P<0.05；t=2.849，P<0.05）。结论：化疗联合斑蝥酸钠维生素B6注射液治疗NSCLC患者的效果较好，且能明显改善NSCLC患者生存质量，其机制可能与降低血清中VEGF水平及升高血清中TNF-α和IL-12水平有关。

关键词: 斑蝥酸钠维生素B6, 癌,非小细胞肺, 生存质量, 血管内皮细胞生长因子, 肿瘤坏死因子α, 白细胞介素12

Abstract: Objective: To investigate the effect of chemotherapy combined with sodium cantharidinate vitamin B6 injection in the patients with non-small cell lung cancer (NSCLC) and its effect on the patients' quality of life, and to clarify its mechanism.Methods: A total of 110 NSCLC patients were divided into chemotherapy group and combined group according to the different treatment methods adopted by the patients. A total of 55 patients were treated with chemotherapy alone (chemotherapy group) and 55 patients treated with chemotherapy combined with sodium cantharidate vitamin B6 injection (combined group). The total effective rate of the patients in two groups were compared; EORTC QLO-C43 scale was used to evaluate the quality of life of the patients in two groups before and after treatment; the serum levels of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and interleukin-12 (IL-12) of the patients in two groups before and after treatment were detected by double-antibody sandwich enzyme-linked immunoassay method.Results: After treatment, the total effective rate of the patients in combined group was higher than that in chemotherapy group, but the difference was not statistically significant (χ²=0.806, P=0.369). Before treatment, there were no significant differences in the scores of functional scale, overall health status, symptom subscale and lung cancer specific subscale of the patients between combined group and chemotherapy group (P>0.05). After treatment, the scores of functional scale and overall health status of the patients in combined group were significantly higher than those in chemotherapy group (P<0.05); the scores of symptom subscale and lung cancer specific subscale of the patients in combined group were significantly lower than those in chemotherapy group (P<0.05). Before treatment, there were no significant differences in the serum levels of VEGF, TNF-α, and IL-12 of the patients between combined group and chemotherapy group (P>0.05). After treatment, the serum level of VEGF of the patients in combined group was significantly lower than that in chemotherapy group (t=3.608, P<0.05), and the serum levels of TNF-α and IL-12 were significantly higher than those in chemotherapy group (t=3.426, P<0.05; t=2.849, P<0.05).Conclusion: The effect of chemotherapy combined with sodium cantharidate vitamin B6 injection in the treatment of the NSCLC patients is good, and it can significantly improve the quality of life of the patients;its mechanism may be related to decreasing the serum VEGF level and increasing the serum TNF-α and IL-12 levels.

Key words: sodium cantharidinate vitamin B6, cancer,non-small cell lung, quality of life, vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin-12

中图分类号:

R734.2

李丽静, 臧亚茹, 于文会, 梁君伟, 佟艳军. 化疗联合斑蝥酸钠维生素B6注射液对非小细胞肺癌患者的治疗效果及其机制[J]. 吉林大学学报(医学版), 2018, 44(06): 1286-1290.

LI Lijing, ZANG Yaru, YU Wenhui, LIANG Junwei, TONG Yanjun. Therapeutic effect of chemotherapy combined with sodium cantharidinate vitamin B6 injection in patientswith non-small cell lung cancer and its mechanism[J]. Journal of Jilin University(Medicine Edition), 2018, 44(06): 1286-1290.

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