背根神经节神经元GABA A型受体对痛觉调制的研究进展

doi:10.13481/j.1671-587x.20180637

摘要/Abstract

摘要： γ-氨基丁酸（GABA）是神经系统中经典的抑制性神经递质，其合成系统和受体系统在动物和人类的背根神经节（DRG）神经元中均已被检测到。在DRG中，GABA系统参与对痛觉信息传入的初级调制，已成为现今痛觉调制研究中的热点，但至今其参与病理性疼痛的机制尚未阐明。GABA的A型受体（GABA_A R）是离子通道型受体，介导快速性抑制反应，在病理性疼痛产生过程中其表达和功能发生改变，很可能成为临床治疗病理性疼痛的重要靶点。GABA_A R有众多亚基，不同亚基组合成的受体功能不同。本文系统地总结了国内外相关文献，就GABA_A R在DRG神经元中的分布、在痛觉信息传递中的作用以及在病理性疼痛发生发展中表达和功能的变化进行综述。

关键词: γ-氨基丁酸, GABAA受体, 背根神经节, 神经元, 病理性疼痛

中图分类号:

R338

成洪聚, 相龙全, 亚白柳, 刘文彦. 背根神经节神经元GABA A型受体对痛觉调制的研究进展[J]. 吉林大学学报(医学版), 2018, 44(06): 1322-1325.

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