microRNA在牙发育和萌出中作用的研究进展

doi:10.13481/j.1671-587x.20180638

摘要/Abstract

摘要： 牙发育是上皮和间充质相互作用的结果，多种信号通路和蛋白质通过影响基因的转录，参与了牙发育和萌出的过程。miRNA作为一种非编码RNA，可通过调控参与牙发育和萌出的信号分子和转录因子，进而影响该过程。在牙发育过程中，miRNA表达谱十分复杂，miRNA表达上调或下调均可引起牙发育和萌出异常。国内有关miRNA对牙发育调控的报道较少。本文结合近几年国内外最近研究进展，主要从miRNA在牙发育各时期的表达、miRNA调控牙发育祖细胞的增殖以及miRNA调控成牙本质细胞和成釉细胞的分化等方面，阐述miRNA在牙发育及萌出中的作用，为牙发育的生物学机制研究提供新思路，为miRNA的临床应用提供新方向。

关键词: 微小RNA, 牙发生, 牙本质发生, 釉质发生, 牙萌出

中图分类号:

R339.35

刘苍维, 张雪, 胡月, 郝新青, 赵欢, 李媛, 闫广兴, 周怡君, 史册, 孙宏晨. microRNA在牙发育和萌出中作用的研究进展[J]. 吉林大学学报(医学版), 2018, 44(06): 1326-1332.

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