Abstract:

Abstract:Objective  To evaluate the diagnostic value of the Montreal Cognitive Assessment (MoCA) in mild cognitive impairment (MCI) by using 25/26 cut-off value with Meta-analyss. Methods PubMed, Medline, VIP, CNKI and WANFANG databases (from January 1 2006 to December 31 2011) were searched to collect studies which evaluated the diagnostic value of MoCA in MCI. The statistical information and quality of science were assessed and classified. The data was analyzed using Meta-Disc1.4 software.The diagnostic value of MoCA in MCI was evaluated by the pooled sensitivity, specificity,and the likelihood ratio. Results Thirteen literatures were collected including 2 in English and 11 in Chinese, and 9 684 subjects were included in the review which were grouped with 6 859 MCI patients and 2 825 cognitive normal individuals, all diagnosed by gold standard. Heterogeneity test showed that the heterogeneity was existed among the study. By using random effects models toanalyze the data, the value of the weighted sensitivity was 0.98(95% CI：0.97-0.98), the specificity was 0.55(95% CI：0.53-0.57),the positive likelihood ratio was 3.67(95% CI：2.67-5.05),and the  negative likelihood ratio was 0.0(95% CI：0.03-0.18). Conclusion The diagnostic ability of MoCA is good. High sensitivity and low specificity are found by using 25/26 as cut-off value. MoCA could be used as a screening test for MCI screening in Chinese population. Considering its low specificity,more detailed researches should be performed to localize this tool, and focus on its cut-off value establishment.

Key words: mild cognitive impairment;Montreal Cognitive Assessment;diagnosis;Meta-analysis