Abstract:

Objective To compare the biochemical and  immunological parameters and histopathological characteristics  in the patients with autoimmune hepatitis
 (AIH),biliary cirrhosis (PBC) and AIH/PBC overlap syndrome,and to provide basis for working out the reference standard of clinical diagnosis and reasonable treatment. Methods 135 cases of autoimmune liver disease patients were selected,including 49 cases of AIH patients,43 cases of PBC patients,and 43 cases of AIH/PBC overlap syndrome  patients.The biochemical,immunological parameters and histopathological changes of the patients were dete
cted.The patients  with  AIH / PBC overlap syndrome were treated with different therapy methods including ursodesoxycholic acid(UDCA) treatment,prednisone treatment and combination treatment with UDCA and prednisone,and   the effectiveness of different treatment programs were evaluated.Results The activities  of  GGT and ALP and IgM level of the patients in the AIH/PBC group were significantly higher than those in   AIH group,there were significant differences (P<0.05);the activities of ALT and AST and IgG level of the patients in  AIH/PBC group was significantly higher than those in  PBC group,there were significant differences (P<0.05).The detection rates of AMA and AMA M2 of the patients in AIH/PBC group were higher than those in AIH group,there were significant differences (P<0.05);the detection rates of ANA and SMA of the patients in AIH/PBC group were higher than those in PBC group,there were significant differences (P<0.05).There were high incidence of piecemeal necrosis (100.0%),liver cell rosette-like changes (83.72%) and bile duct lesions (69.77%) of the patients in AIH/PBC group.The effective percentage in combination therapy group was 85.7% which was significantly higher than those in various drug alone groups (P<0.05).Conclusion The changes of biochemical and immunological indicators  and pathological features of the patients with   AIH/PBC overlap syndrome are in  combination with the particular indicators of AIH and PBC which  would provide the diagnostic basis for AIH/PBC overlap syndrome.The combined therapy for AIH/PBC overlap syndrome is effective and should be popularized.

Key words: liver cirrhosis, biliary；hepatitis, autoimmune；overlap syndrome