兔血液中乌头碱代谢产物的研究

兔血液中乌头碱代谢产物的研究

张宏桂¹，史向国²，孙莹³，钟大放²，张寒琦¹

1．　吉林大学化学学院，长春 130012； 2．　沈阳药科大学药物代谢与药物动力学实验室，沈阳 110016； 3．　长春高等医学专科学院，　长春 130031）

收稿日期:2005-03-07 修回日期:1900-01-01 出版日期:2006-03-26 发布日期:2006-03-26
通讯作者: 张寒琦

Study on the Metabolites of Aconitine in Rabbit Blood

ZHANG Hong-gui¹, SHI Xiang-guo², SUN Ying³, ZHONG Da-fang², ZHANG Han-qi¹

(1. College of Chemistry, Jilin University, Changchun 130012, China; 2. Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Shenyang 110016, China; 3. Changchun Medical College, Changchun 130031, China)

Received:2005-03-07 Revised:1900-01-01 Online:2006-03-26 Published:2006-03-26
Contact: ZHANG Han-qi

摘要/Abstract

摘要： 用液相色谱电喷雾离子阱多级质谱法首次从中毒死亡7 d家兔血液中分离鉴定了乌头碱及其3种代谢产物，其中16-O-去甲基乌头次碱为首次在口服乌头碱动物血液中发现，并研究了乌头碱在兔血液中代谢的途径.

关键词: 乌头碱, 代谢物, 液相色谱-电喷雾离子阱质谱法

Abstract: Aconitine and its three metabolites were separated and identified in the blood of dead rabbits after aconitine poisoning by means of liquid chromatography-electrospray ion trapmass spectrometry (LC-ESI-MS). 16-O-demethylbenzoylaconine in the blood of the animal that was administered aconitine was found for the first time. The metabolic pathway of aconitine in the blood was studied.

Key words: aconitine, metabolite, liquid chromatography-electrospray ion trap-mass spectrometry

中图分类号:

R927

张宏桂，史向国，孙莹，钟大放，张寒琦. 兔血液中乌头碱代谢产物的研究[J]. J4, 2006, 44(02): 284-286.

ZHANG Hong-gui, SHI Xiang-guo, SUN Ying, ZHONG Da-fang, ZHANG Han-qi. Study on the Metabolites of Aconitine in Rabbit Blood[J]. J4, 2006, 44(02): 284-286.

[1]	孙莹, 张群书, 董丽丹，陈玉娟. 乌头属中药中主要生物碱在不同性别家兔尿中的代谢产物[J]. J4, 2007, 45(06): 1032-1034.
[2]	张宏桂,马辰,巫毅,刘爱茹,张寒琦. 复方酒剂中乌头碱含量的测定及其中毒剂量的研究[J]. J4, 2005, 43(05): 677-679.