2-氧杂双环［3,3,0］辛-6-烯-3-酮对映异构体手性拆分及光学纯度的测定

Journal of Jilin University Science Edition ›› 2019, Vol. 57 ›› Issue (06): 1530-1534.

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Chiral Separation of Enantiomer of 2-Oxabicyclo［3,3,0］oct-6-en-3-oneand Determination of Optical Purity#br#

CAO Hong^1,2, WANG Shuhong³, ZHAO Chunying³, HU Chuanmin¹, CAI Jianhui¹, XIU Zhiming¹

1. Jilin Collaborative Innovation Center for Antibody Engineering, Jilin Medical University, Jilin 132013, Jilin Province, China; 2. The ChinaJapan Union Hospital of Jilin University, Changchun 130021, China;3. Changchun BC＆HC Pharmaceutical Technology Co., Ltd, Changchun 130012, China

Received:2019-08-02 Online:2019-11-26 Published:2019-11-21
Contact: XIU Zhiming E-mail:Xiuzm10@mails.jlu.edu.cn

Abstract

Abstract: The chiral silicon surface coated with cellulosethree (3,5dimethylphenyl carbamate) was used as stationary phase, the solvent of V(nhexane)∶V(isopropyl alcohol)=95∶5 was used as mobilephase to separate 2-oxabicyclo［3,3,0］oct-6-en-3-one. The flow rate was 08 mL/min, the column temperature was 25 ℃, and detection wavelength was 205 nm. The results show that the resolution is 3.0, the enantiomer can be effectively separated, and the optical purity can be determined by area normalization method.

Key words: 2-oxabicyclo［3,3,0］oct-6-en-3-one, enantiomer, separation, optical purity

CLC Number:

O641.6

CAO Hong, WANG Shuhong, ZHAO Chunying, HU Chuanmin, CAI Jianhui, XIU Zhiming. Chiral Separation of Enantiomer of 2-Oxabicyclo［3,3,0］oct-6-en-3-oneand Determination of Optical Purity#br#[J].Journal of Jilin University Science Edition, 2019, 57(06): 1530-1534.

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Chiral Separation of Enantiomer of 2-Oxabicyclo［3,3,0］oct-6-en-3-oneand Determination of Optical Purity#br#

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