关键词: 急性心肌梗死, 经皮冠状动脉介入治疗, 血糖, 白细胞介素6;血小板源性生长因子

Abstract:

Abstract:Objective To study the effects of blood glucose concentration  on the levels of IL-6 and platelet derived growth factor(PDGF) before and after operation and short-term prognosis in patients with acute myocardial infarction(AMI) treated by primary percutaneous coronary intervention (PCI),and discuss the possible mechanisms of those effects. Methods A total of 54 patients with AMI treated with successful primary PCI within 10 h after onset of symptoms were divided into three groups:  groupⅠ,non-diabetic patients with blood glucose level<8.0 mmol·L-1;group Ⅱ,non-diabetic patients with blood glucose level ≥8.0 mmol·L-1;group Ⅲ,diabetic patients. The method of enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of blood serum IL-6 and PDGF  before PCI 10 min and 24 and 48 h after   PCI. Results There were no  differences in the incidence rates of serious arrhythmia in operation and heart failure duration of hospital between three groups（P<0.05）,but the incidence rates in group Ⅲ and group Ⅱ were higher than that in group Ⅰ. The levels of IL-6 and PDGF were increased with blood glucose level in three groups,group Ⅲ >group Ⅱ> group I,there were significant differences (P<0.05). The level of IL-6 48 h after PCI in group Ⅰ was decreased to the level before PCI,the descent in group Ⅱ and Ⅲ was slow. The  PDGF levels  24 and 48 h after PCI had been little higher than before PCI in group I，the level of PDGF in group Ⅱ was lower than that in group Ⅲ and higher than that in group Ⅰ(P<0.05). Conclusion Stress hyperglycemia in patients with AMI treated by primary PCI maybe increase the levels of inflammatory reaction，extend the time of inflammatory reaction，increase the incidence rates of serious cardiac arrhythmia in operation and heart failure duration of hospital stay.

Key words: acute myocardial infarction;percutaneous coronary intervention;blood glucose;interleukin-6;platelet derived growth factor