关键词: 雌激素受体, 孕激素受体, 乳管镜, 乳腺疾病

Abstract: Objective To investigate the value of the expressions of estrogen receptor(ER) and progesterone receptor (PR) in the cast-off cells from the fluid of latex ductal lavage in the diagnosis and treatment of breast diseases. Methods A total of 58 female out-patients were examined by fiberoptic ductoscopy (FDS). All patients were divided into 6 groups by the complaints, physical examination, ultrasound and FDS:normal group (10 persons without symptoms and abnormalities in any examination),galactostasis group (n=19), latex fill up group (n=11), intraductal papilloma group (n=2), mammary ductal ectasia group (n=7) and contralateral examination after mastectomy for breast cancer group(n=9). A total of 168 ducts were successfully examined by FDS, and the expressions of ER and PR in the cast-off cells were detected among all of the samples. Results The positive rates of ER and PR expression in the cast-off cells from the fluid of latex ductal lavage in benign breast disease groups were much higher than those in normal group (P<0.05). The positive rates of ER and PR expression in the cast-off cells from the fluid of abnormal ducts detected by FDS were also much higher than those in normal ducts (P<0.05) in the same case of breast disease. The expression rates of ER and PR in the cast-off cells in normal group showed no significant difference as compared with normal ducts detected by FDS in the abhormal breast. Conclusion The local high expressions of ER and PR are associated with the high risk of breast diseases. The detection of ER and PR expressions plays an important role in guiding the treatment and judging the risk factors of breast diseases.

Key words: estrogen receptor, progesterone receptor, fiberoptic ductoscopy, breast diseases