Abstract:

Objective
To investigate the changes of homocysteic acid (Hcy) and C-reactive protein (CRP) levels in blood plasma of elderly patients with coronary heart disease and elucidate the risk factors of elderly patients with coronary heart disease.Methods 90 elderly patients with coronary heart disease were divided into 3 groups:stable angina pectoris group (SAP)(n=30),unstable angina pectoris group(UAP)(n=30),acute myocardial infarction group(AMI)(n=30).30 healthy elderly persons elder than 60 years old were enrolled as control group.Venous blood of all persons was harvested during empty stomach and plasma was separated.Then plasma Hcy and CRP were determined.
Results The TC and TG levels in the three elderly coronary heart disease groups were significantly higher than those in control group （P<0.05）. Especially the TG level increased following with the increase of severe degree of elderly coronary heart disease.The Hcy and CRP levels in the three elderly coronary heart disease groups were significantly higher than those in control group （P<0.05）.There were significant differences of  plasm Hcy and CRP levels between three elderly coronary heart disease groups（P<0.05）.The plasma Hcy and CRP levels increased following with the increase of severe degree of elderly coronary heart disease.Conclusion Elderly coronary heart disease is related to Hcy emia and the increase of CRP level.This demonstrates that Hcy emia and the increase of CRP level may be risk factors for elderly coronary heart disease.At the same time,the abnormality of blood fat is related to Hcy  emia and the increase of CRP level.Following with the increase of severe degree of elderly coronary heart disease,the plasm Hcy and CRP levels increase,too.So severe degree of elderly coronary heart disease can be predicted through determination of plasm Hcy and CRP levels.

Key words: homocysteic acid/diagnostic use;C-reactive protein hyperlipidemia;coronary , disease