Abstract:

Abstract:Objective To observe the the protective effect of combination of low dose fosinopril and erbasartan  on experimental myocardial infarction in rats and its mechanism.Methods Wistar rats were randomly divided into sham operation,model,fosinopril (20 mg·kg^-1),erbasartan (100 mg·kg^-1) and  fosinopril + erbasartan(10 mg·kg^-1+50 mg·kg^-1) groups.The acute myocardial infarction models were established with ligation of left anterior descending coronary artery in rats except  sham operation group. The effects of fosinopril and erbasartan and  combination of fosinopril and erbasartan on myocardial infarct size (MIS) and the activities of serum creatine phosphokinase (CK),lactate dehydrogenase (LDH) and aspartate aminotransferase (AST),the contents of plasma endothelin (ET) and angiotensinⅡ(AngⅡ), the level of myocardial free fatty acid (FFA) in ischemic and non-ischemic area,and the viscosities of blood and plasma were determined.Results Compared with  model group,the MIS in  sham operation,fosinopril,erbasartan and  fosinopril + erbasartan groups was significantly reduced (P<0.05　 or P<0.01),the activities of serum CK,LDH and AST were significantly decreased (P<0.05 or P<0.01),the contents of plasma ET and the levels of myocardial FFA in ischemic area were significantly decreased (P<0.05),and the viscosities of blood and plasma were also significantly decreased (P<0.05),but the contents  of plasma AngⅡ and the levels of myocardial FFA in non-ischemic area had no significant changes.Conclusion Low dose fosinopril combined with  erbasartan  has protective effect on acute myocardial infarction in rats,just as high dose fosinopril or erbasartan,by reducing damage of FFA and ET on myocardium,improving myocardial metabolism,correcting state of bloodstream in myocardial ischemia and preventing thrombosis etc.

Key words: fosinopril;erbasartan;myocardial infarction;myocardial enzyme;endothelin;angiotensinⅡ;rats,Wistar