Abstract:

Abstract:Objective To assess the efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia and the differences in adverse effects of them．Methods Meta analysis  on  the 14 papers about efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia was performed,and  the total effective rate,cure ratative,obvious effective rate and adverse effects were evaluated.Results ①Haloperidol and quetiapine had similar total effective rate (P=0.76);②there was significant difference of curative rate between haloperidol and quetiapine in treatment of schizophrenia(P=0.04);③Compared with haloperidol,quetiapine had a higher obvious effective rate(P=0.006);④the  incidence rates of akathisia,myotonia,dry mouth etc in quetiapine group were lower than those in haloperidol group (P<0.05).Conclusion Quetiapine is better than haloperidol on the cure rate and obvious effective rate in the treatment of schizophrenia．Further,quetiapine has less extrapyramidal reactions.

Key words: quetiapine；haloperidol；schizophrenia;meta , analysis