Abstract:

Objective To explore the application of tumor markers AFP,CA125,CA199 and CEA in diagnosis and  treatment for the patiants with viral hepatitis and liver cirrhosis,and estimate  the values of 4 indicators in  judgement of  liver damage degree  and early detection of liver cancer. Methods Automatic electrochemical technology of light was used to detect the serum AFP,CA125,CA199 and CEA levels in 102 patients with liver diseases (55 cases of chroic hepatitis,of which  mild 24 cases,moderate 21 cases,severe 10 cases;47 cases of liver cirrhosis following hepatitis )and 22 healthy subjects.Results The AFP and CA199 levels in patients with chronic hepatitis were obviously higher than those in control group,the AFP levels in mild,moderate,and severe groups were 2.8,4.8, and 20.0  μg/L^-1,the CA199 levels were 12.20,18.40 and 39.10 U/mL^-1,it had  a rising trend with  disease progression(P< 0.05);the CA125 levels in chronic hepatitis patients were 7.95,18.08 and 54.32 U/mL^-1,the CA125 levels in moderate  and severe groups were  higher than that in  control group,the difference was statistically significant (P< 0.05);but there was no statistically significant difference between moderate and server groups(P> 0.05). The positive rates of AFP,CA199,and CA125  in patients with liver cirrhosis were 27.7%,55.3%, and 65.9%,and they were higher than those in hepatitis group （10.9%,25.5%,29.1%）(P< 0.05). The  positive
 rate  of CEA had no significant difference  between  hepatitis and liver cirrhosis groups(P>0.05). The AFP,CA199, and CA125 in  the  patients with decompensated  liver cirrhosis were 20.05  μg/L^-1,53.03 U/mL^-1, and 144.80 U/mL^-1,and they were significantly  higher than those in compenstatory cirrhosis(14.45  μg/L^-1, 24.45 U/mL^-1,and 30.10 U/mL^-1 )(P< 0.05).Conclusion  The AFP and CA199 levels are increaesd  with the degree of liver damage,and they can be used as evaluation index of the non-invasive diagnosis of liver damage.For viral hepatitis and liver cirrhosis patients with AFP rising,dynamic monitoring of AFP level has the important meaning for early detection of liver cancer.CA125 can be used to identify compensatory cirrhosis with decompensated cirrhosis,and has early diagnosis value in trace ascites.

Key words: alpha fetoprotein;carcino-embryonic antigen;carbohydrate antigen 199;cancer antigen 125;
hepatitis, viral;liver cirrhosis