Abstract:

Objective  To study the protective effect of extract of buckwheat chaff (EBC mellitus) on myocardial injury in  type 2 diabetes mellitus (T2DM)
 rats and  to disscuss its mechanism.Methods T2DM rat  models were established  by injecting streptozotocin (STZ) and given high-fat diet.
23 T2DM rats were divided into model control group (n=8),EBC treatment group (n=7),and benazepril treatment group (n=8).Another 7 SD rats were selected as normal control group.The rats in EBC treatment group and benazepril treatment group were administered with EBC （200 mg/kg-1/d-1）
and benazepril （4 mg /g-1/d-1）orally.While the rats in other two groups were administered with　normal water (10 mL/kg-1/d-1) instead.The levels of fasting blood glucose (FBG),body weight (BW),cardiac index (HWI),heart rate (HR),left ventricular systolic blood pressure(LVSP),left ventricular dia stolic pressure(LVEDP) and ±dp/dtmax
　of  rats were measured 8 weeks after treatment  in various  groups.The  morphological  changes of myocardium tissue of  rats were observed with light
microscope.Results Compared with normal control group,the FBG,HWI,LVEDP of the rats  in model group were increased(P<0.01), and the BW,LVSP,HR,and ±dp/dtmax in model control groups were decreased(P<0.05 or P<0.01).Compared with model control group,the BW,LVSP,HR,and ±dp/dtmax were i
ncreased and the  HWI,FBG and LVEDP  of the rats in EBC and benazepril treatment groups were decreased(P<0.05 or P<0.01).The morphology of myocardium tissue
of  the rats in EBC treatment and benazpril treatment groups were improved.Conclusion EBC can improve the histomorphology  of myocardium tissue of the T2DM rats,and its mechanism may be related to up-regulating  the  LVSP,HR and ±dp/dtmax and down-regulating  the  LVEDP.
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Key words:  , buckwheat, extract of buckwheat chaff, type 2 diabetes mellitus, glucose, cardiac function