Abstract:

Objective  To study the expressions of casein kinase 2α(Ck2α),β-catenin,survivin in ovarian cancer tissue and analyze the relationships between them, and to explore the clinical application value.Methods Immunohistochemistry staining  was used to detect the expressions of Ck2α,β-catenin and survivin in 8 cases of simple ovarian cysts tissue,8 cases of ovarian benign tumor tissue and 29 cases of ovarian cancer tissue;  the correlations   of  the expressions of Ck2α,β-catenin,survivin in ovarian cancer tissue andtheir  associations with the clinicopathologic characteristics were analyzed.Results The expression
levels of Ck2α, β-catenin and survivin in ovarian cancer tissue were significantly higher than those in simple ovarian cysts  tissue and ovarian benign tumor tissue(P<0.05);the Ck2α expression level   in ovarian cancer tissue  was positively corelated with  the expression levels of β-catenin and survivin
(r=0.438,r=0.479,P<0.05);the expression levels of Ck2α,β-catenin and survivin in  low-medium differentiation group were significantly higher
 than those in high differentiation group (P<0.05);the expression levels of Ck2α,β-catenin and survivin in stagesⅡand Ⅲ group
 were significantly higher than those in  stage Ⅰ group(P<0.05).Conclusion The protein expression levels of Ck2α,β-catenin and survivin are  increased in ovarian cancer tissue,and three are positive corelations between them;Ck2α,β-catenin and survivin  may play an important role in the occurrence and development of ovarian cancer;the combined detection of them has important clinical value.
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Key words: casein kinase 2&alpha, &beta, -catenin, survivin, ovarian neoplasms