Forty rats were selected， ten rats were randomly selected as normal group， ten rats were used as blocker control group， and the other 20 rats were used to construct partial hepatectomy models. Sixteen modeling rats were randomly divided into model group and model + blocker group， and there were eight rats in each group. The rats in model + blocker group were injected with 0.5% lidocaine on both sides of the celiac plexus before abdominal closure， and the rat models were not prepared in blocker control group and the rats were injected with 0.5% lidocaine on both sides of the celiac plexus； the rats in normal group and model group were injected with the same amount of normal saline. At 12 h after of administration， the levels of cocorticoid （CORT），adrenocorticotropic hormone （ACTH）， noradrenaline （NE）， tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， and interleukin-6 （IL-6） in serum of the rats in various groups were measured by ELISA method；Real-time fluorescence quantitative PCR （RT-qPCR） and Western blotting methods were used to detect the expression levels of glucocorticoid receptor （GR） and Toll-like receptor 4 （TLR4） mRNA and proteins in the peripheral blood mononuclear cells of the rats in various groups.

Compared with normal group and blocker control group， the levels of CORT， ACTH and NE in serum of the rats in model group and model + blocker group were increased （P<0.05）； compared with model group， the levels of CORT， ACTH， and NE in serum of the rats model + blocker group were decreased （P<0.05）. Compared with normal group and blocker control group， the levels of TNF-α， IL-1β and IL-6 in serum of the rats in model group and model + blocker group were increased （P<0.05）； compared with model group， the levels of TNF-α， IL-1β， and IL-6 in serum of the rats in model + blocker group were decreased （P<0.05）. Compared with normal group and blocker control group， the expression levels of GR mRNA and protein in the peripheral blood mononuclear cells of the rats in model group and model+blocker group were increased（P<0.05）， while the expression levels of TLR4 mRNA and protein were decreased （P<0.05）； compared with model group， the expression levels of GR mRNA and protein in the peripheral blood mononuclear cells of the rats in model + blocker group were increased（P<0.05）， while the expression levels of TLR4 mRNA and protein were decreased （P<0.05）. There were no significant differences in the serum levels of CORT， ACTH， NE， TNF-α， IL-1β， and IL-6， and the expression levels of GR and TLR4 mRNA and proteins in peripheral blood mononuclear cells of the rats between normal group and blocker control group （P>0.05）.

Celiac plexus block can reduce the stress response and immune inflammatory response of the rats after partial hepatectomy， and its mechanism may be related to up-regulating the GR protein expression and down-regulating the TLR4 protein expression.