Perfusion and digestion methods were used in 30 SPF KM mice to isolate the primary LSEC. The cells were divided into blank control group， model group， curcumol group， and salvianolic acid B group. The cells in blank control group were treated with ordinary culture medium only； the cells in model group were activated with 100 μg·L^－1 serotonin， and the cells were cultured for 48 h； the cells in curcumol group were treated with 45 mg·L^－1 curcumol for 30 min and then the cells were cultured with serotonin for 48 h； the cells in salvianolic acid B group were first treated with 1×10^－6 mmol·L^－1 salvianolic acid B for 30 min and then cultured with alicin for 48 h. MTT assay was used to detect the proliferation rates of the cells in various groups； Real-time fluorescence quantitative polymerase chain reaction（RT-qPCR） method was used to determine the expression levels of CD31 and vWF mRNA in the cells in various groups； Western blotting method was used to detect the expression levels of CD31 and vWF proteins in the cells in various groups； scanning electron microscope was used to observe the structure of the LSEC； angiogenesis experiment was used to observe intrahepatic angiogenesis.

The MTT test results showed that the proliferation rate of the cells in model group was significantly lower than that in blank control group （P<0.05）； the cell proliferation rates in curcumol group and salvianolic acid B group were significantly lower than that in model group （P<0.05）；there was no significant difference in the cell proliferation rate between salvianolic acid B group and curcumol group （P>0.05）. The results of RT-qPCR showed that the expression levels of CD31 and vWF mRNA in the cells in model group was significantly higher than those in blank control group （P<0.05）； the expression levels of CD31 and vWF mRNA in curcumol group and salvianolic acid B group were significantly lower than those in model group （P<0.05）；there were no significant differences in the expression levels of CD31 and vWF mRNA between salvianolic acid B group and curcumol group（P>0.05）. The results of Western blotting method showed that the expression levels of CD31 and vWF proteins in the cells in model group were significantly higher than those in blank control group （P<0.05）； the expression levels of CD31 and vWF proteins in the cells in salvianolic acid B and curcumol group group were significantly lower than those in model group （P<0.05）； there were no significant differences in the expression levels of CD31 and vWF proteins between salvianolic acid B group and curcumol group（P>0.05）. The results of scanning electron microscope showed that the number of LSEC fenestrations of LSEC in blank control group was larger； compared with blank control group， the number of LSEC fenestrations in model group was decreased； compared with model group， the number of LSEC fenestrations in curcumol group and salvianolic acid B group was increased. The angiogenesis experiment results showed that the number of blood vessels in model group was significantly increased compared with blank group （P<0.05）；the number of blood vessels in curcumol group and salvianolic acid B group was significantly lower than that in model group （P<0.05）； and there was no statistically significant difference in the number of blood vessels between salvianolic acid B group and curcumol group （P>0.05）.

Curcumol can inhibit the intrahepatic angiogenesis by regulating the fenestration structure of LSEC.