A total of 100 healthy female SD rats during estrus and 50 male SD rats were caged， and 60 pregnant female rats were selected. Nine rats were randomly selected as normal group， and the other 51 rats were used to establish the pathological models of incomplete uterine involution after drug abortion. A total of 40 successfully modeled rats were randomly divided into model group， activator group， activator +leonurus alkaloid group and leonurus alkaloid group（n=10），and the rats were given phosphatidylinositol 3-kinase （PI3K）/protein kinase B （AKT） signaling pathway activator insulin-like growth factor-1 （IGF-1）， PI3K/AKT activator IGF-1+total alkaloids of leonurus and total alkaloids of leonurus by gavage， and the rats in normal group were given equal volume of normal saline by gavage. The bleeding volume， coagulation time， wet weight，and coefficient of the urerus， tension and contractility of uterus smooth muscle of the rats in various groups were detected. The morphology of uterine tissue of the rats in various groups was observed by HE staining， the expression levels of estrogen receptor （ER） in decidual tissue of the rats in various groups were detected by immunohistochemistry， and Western blotting method was used to detect the expression levels of p38 mitogen activated protein kinase （p38MAPK），PI3K，phosphorylated PI3K（p-PI3K），AKT and phosphorylated AKT （p-AKT） proteins in decidual tissue of uterus of the rats in various groups.

Compared with normal group， the bleeding volume， coagulation time， weight and coefficient of uterus of the rats in activator group， model group， activator+leonurus alkaloid group and leonurus alkaloid group were decreased （P<0.05）， the tension and contractility of uterine smooth muscle were increased （P<0.05）， the expression levels of ER in decidual tissue of uterus were increased （P<0.05）， and the ratios of P-P38MAPK / p38MAPK， p-PI3K/PI3K and p-AKT/AKT in decidual tissue of uterus were decreased （P<0.05）； compared with activator group， the bleeding volume， coagulation time， uterus weights and uterus coefficients of the rats in model group， activator+leonurus alkaloid group and leonurus alkaloid group were increased （P<0.05）， the tensions and contractilities of uterine smooth muscle were increased （P<0.05）， and the expression levels of ER in decidual tissue of uterus were increased （P<0.05） and the ratios of p-P38MAPK / p38MAPK， p-PI3K / PI3K and p-AKT/AKT in decidual tissue of uterus were decreased （P<0.05）；compared with model group， the bleeding volume of uterus of the rats in activator+leonurus alkaloid group and leonurus alkaloid group were decreased （P<0.05）， the coagulation time was prolonged， the tensions and contractility of the uterine smooth muscle were increased （P<0.05），the expression levels of ER in decidual tissue of the uterus were increased （P<0.05）， and the ratios of p-P38MAPK/p38MAPK， p-PI3K/PI3K and p-AKT/AKT in decidual tissue of uterus were decreased （P<0.05）； compared with activator+leonurus alkaloid group， the bleeding volume of uterus of the rats in leonurus alkaloid group was decreased （P<0.05）， the coagulation time was prolonged（P<0.05），the tension and contractility of uterine smooth muscle were increased （P<0.05）， and the expression level of ER in decidual tissue of uterus was increased（P<0.05），and the ratios of p-p38MAPK/p38MAPK，p-PI3K/PI3K and p-AKT/AKT in decidual tissue of uterus were decreased （P<0.05）.There were a large amount of congestion and decidual cells in the rats in activator group and model group. There was no congestion and decidual cells decreased significantly in the activator+leonurus alkaloid group and leonurus alkaloid group.

The total alkaloids of leonurus can promote the excretion of decidual villi tissue of the drug abortion rats， which may be achieved by inhibiting the MAPK/PI3-K/AKT signaling pathway.