HIV-1 Tat蛋白的翻译后修饰对HIV-1转录和复制调控机制影响的研究进展

doi:10.13481/j.1671-587X.20260328

Abstract

Abstract:

Human immunodeficiency virus （HIV） is a kind of virus that attacks the host immune system and causes acquired immunodeficiency syndrome（AIDS） in infected individuals， which seriously endangers human health. Trans-activator of transcription （Tat）， a small non-structural protein encoded by HIV， binds to the trans-activation response element （TAR） of HIV to promote the transcription of viral genome， and this effect is closely related to multiple post-translational modifications of Tat protein. This paper reviewed the different types of post-translational modifications （phosphorylation， acetylation， ubiquitination and methylation） of HIV-1 Tat protein， and summarized the main action sites of related post-translational modifications on Tat protein as well as their regulatory mechanism on HIV-1 transcription and replication. Such modifications not only affect the structure and stability of Tat protein， but also regulate its transcriptional activity and its interaction with host proteins， and ultimately affect viral replication and latency. Therefore， in-depth study on post-translational modifications of Tat protein not only helps to understand the molecular mechanism of HIV infection， but also provides a theoretical basis for the development of novel antiviral therapeutic targets.

Key words: Human immunodeficiency virus, Trans-activator of transcription protein, Trans-activation response element, Immune system, Post-translational modification

CLC Number:

R512.91

Jiaxiang ZHANG,Yang CAO,Chen HUAN. Research progress in impact of post-translational modifications of HIV-1 Tat protein on regulatory mechanisms of HIV-1 transcription and replication[J].Journal of Jilin University(Medicine Edition), 2026, 52(3): 854-862.

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References 56

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Research progress in impact of post-translational modifications of HIV-1 Tat protein on regulatory mechanisms of HIV-1 transcription and replication

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