吉林大学学报(工学版) ›› 2011, Vol. 41 ›› Issue (6): 1704-1708.

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New method to discover human encoded microRNAs for regulating gene segments of influenza virus

LIU Yuan-ning1,2, LI Xin1,2, ZHANG Hao1,2, SHEN Ting-jie1,2, LI Zhi3, TIAN Ming-yao4, LU Hui-jun4   

  1. 1.College of Computer Science and Technology, Jilin University, Changchun 130012, China|2.Symbol Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China|3.School of Computer Science and Technology, Changchun University of Science and Technology, Changchun 130022, China|4.Institute Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, China
  • Received:2010-12-06 Online:2011-11-01 Published:2011-11-01

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Abstract:

A MiR-CR method was proposed based on conserved regions of influenza virus genes to discover human encoded miRNAs that regulate influenza virus. HA, NA, NP, PB2 and PA are taken as examples, seven human encoded miRNA are discovered. The result needs further experimental verification. Because the research of the miRNAs influenza gene expression in the infection is still in the early stage, the result of this work is of importance to discover the changing regularity of influenza pathogenicity and infection and apply in drug molecular design.

Key words: bioinformatics, human encoded miRNAs, influenza virus, conserved region

CLC Number: 

  • TP399
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