关键词: 电场刺激, 周期峰放电, 放电频率, 神经性疾病

Abstract: In order to solve the problems of effectiveness and safety of electromagnetic stimulation in the treatment of epileptic neurological diseases，the equal effect model of pyramidal neurons in hippocampal ca3 region，which is prone to epileptic seizures，was established． The firing activity of the neurons was studied through Matlab simulation under the conditions of both direct-current and alternating-current electric field． The results are as follows: first，neuron firing frequency is modulated by direct-current electric field，and greatly sensitive to the direction of the electric field． The dynamic characteristics of neurons were affected significantly by the change of the electric field intensity when the direction of the field was negative; the effects were not significant when the direction of field was positive． Second，the dynamic characteristics of neurons showed great dependence on the external field frequency by alternating-current electric field stimulation． The neurons firing may appear discharging status such as period bursting，synchronized spiking，period spiking，and chaotic firing by different stimulation frequency． It has great theoretical significance to treat the neurological disorders such as Epilepsy by means of electromagnetic field therapy，by which the discharging status of neurons can be affected better by alternating-current electric field than that by direct-current electric field． It will be helpful for doctors to make secure and efficient therapy schedules to treat neurological disorders with the method of electromagnetic fieldtherapy．

Key words: electric field stimulation, period spiking, firing frequency, neurological