To achieve high efficiency, lowpower regional positioning, we combine mainstream WSN(Wireless Sensor Network)location algorithm, bring up a weighted centroid localization method using RSSI(Received Signal Strength Indication), and build a wireless sensor network, formulate an efficient communication protocol. Based on communication protocol, first the PC sends instruction to poll the target node, and then target node broadcasts acknowledgement, finally PC
computes coordinate of the target with the aggregation data from anchor-nodes. The results fully prove that the method can efficiently locate the target node, reduce target node power consumption, which can place an important role in location application.