乌头属中药中主要生物碱在不同性别家兔尿中的代谢产物

乌头属中药中主要生物碱在不同性别家兔尿中的代谢产物

孙莹¹, 张群书², 董丽丹³，陈玉娟⁴

1. 长春医学高等专科学校, 长春 130031; 2. 沈阳药科大学药学院，沈阳 110016;3. 长春市药品检验所, 长春 130051; 4. 吉林大学药学院, 长春 130021

收稿日期:2006-12-27 修回日期:1900-01-01 出版日期:2007-11-26 发布日期:2007-11-26
通讯作者: 孙莹

Metabolites of Major Alkaloids of Aconitum Chinese Herbal Medicinein Different Gender Rabbit Urine

SUN Ying¹, ZHANG Qun shu², DONG Lidan³, CHEN Yujuan⁴

1. Changchun Medical College, Changchun 130031, China;2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;3. Changchun Institute for Drug Control, Changchun 130051, China;4. College of Pharmacy, Jilin University, Changchun 130021, China

Received:2006-12-27 Revised:1900-01-01 Online:2007-11-26 Published:2007-11-26
Contact: SUN Ying

摘要/Abstract

摘要： 考察动物性别对尿中乌头碱代谢产物的影响. 用液相色谱电喷雾离子阱多级质谱法分别从雄性和雌性家兔尿中检测到乌头原碱、乌头次碱、 16-O-去甲基乌头次碱、 16-O-去甲基乌头碱和乌头碱, 并从雄性家兔尿中检测到去乙酸乌头碱, 为法医鉴定及临床检验提供了乌头碱中毒的判别依据.

关键词: 乌头碱, 代谢物, 液相色谱电喷雾离子阱质谱法

Abstract: To investigate whether or not aconitine metabolism is affect by sexual distinction, aconitine and its five metabolites were separated from the urine of female and male rabbits and identified after aconitine poisoning by means of liquid chromatographyelectrospray ion trapmass spectrometry (LC-ESI-MS) which is useful in identifying aconitine poisoning in forensic medicine.

Key words: aconitine, metabolite, liquid chromatographyelectrospray ion trapmass spectrometry

中图分类号:

R927

孙莹, 张群书, 董丽丹，陈玉娟. 乌头属中药中主要生物碱在不同性别家兔尿中的代谢产物[J]. J4, 2007, 45(06): 1032-1034.

SUN Ying, ZHANG Qun shu, DONG Lidan, CHEN Yujuan. Metabolites of Major Alkaloids of Aconitum Chinese Herbal Medicinein Different Gender Rabbit Urine[J]. J4, 2007, 45(06): 1032-1034.

[1]	张宏桂，史向国，孙莹，钟大放，张寒琦. 兔血液中乌头碱代谢产物的研究[J]. J4, 2006, 44(02): 284-286.
[2]	张宏桂,马辰,巫毅,刘爱茹,张寒琦. 复方酒剂中乌头碱含量的测定及其中毒剂量的研究[J]. J4, 2005, 43(05): 677-679.