Abstract:

The BSAPLG microspheres were prepared by S/W/O/W emulsion solvent evaporation method with biodegradable material PLG607 as the carrier. Drug encapsulation capacity, morphology, particle size characteristics, as well as invitro release profiles of the microspheres were discussed. The results show that the microspheres were spherical and smooth and the mean size of the microspheres was 40~70 μm, with a mono dispersibility. The invitro release profiles of the microspheres produced from different methods were significantly distinct. With the additives of hydroxypropylβcyclodextrin (HPB) and hydroxyapatite (HAP), the encapsulation of microspheres increased from 27.9% to 46.3%. Therefore, using S/W/O/W method and adding additives HAP and HPB in the formulation could decrease the initial burst release of drugs from the microspheres and increase the encapsulation capacity of the BSAPLG microspheres, the invitro release profiles of which were fitted into near zero order release kinetics.

Key words: S/W/O/W method, poly(lactide\, co\, glicolide), bovine serum albumin, microsphere