关键词: TLR8基因, 单核苷酸多态性, 肺结核

Abstract: Objective To explore the correlation between  single nucleotide
polymorphism (SNP) of four sites on  the Toll-like receptor  8 (TLR8) gene and
tuberculosis in Han population from Northeast china,and to analyze the differences of genotypic frequency
distribution between tuberculosis and other lung diseases patients. Methods
A case-control study for 368 cases of tuberculosis patients (case group) and 355 other lung disease patients (control group) in Han population from Northeast China was established.The ligase specific
detection technology was carried out to detect the genotypes of   rs3764880,rs3761624,rs3788935, and rs3764879 sites on   TLR8 gene in two groups.The
 distribution  of  allelic frequencies (GF)  of the patients in two groups were compa
red  and the odds ratio (OR)  and the distribution of genotypic frequencies of the  patients with different gender  were analyzed.Results The　 allelic frequency distribution of   rs3764880,rs3761624,rs3788935,and rs3764879 sites on   TLR8 gene between case group and control group was not statistically
 significant(P>0.05);the  distribution of allelic frequency of four sites on  TLR8 gene   of patients with different gender 
between  case group and control group was not statistically significant(P>0.05).Conclusion The distributions of SNP at  rs3764880,rs3761624,rs3788935,and rs3764879 sites on   TLR8 gene are same  between tuberculosis and other lung disease patients in H
an population from Northeast China,which indicates that there is no association between SNP of four sites on TLR8 gene and the occurrence of tuberculosis.

Key words: Toll-like receptor 8 gene, single nudeotide polymorphism, tuberculosis