关键词: 过敏性, 血液, 肾炎, 血液, 紫癜性肾炎, 一氧化氮, 血液, 内皮缩血管肽1, 血液

Abstract: Objective To investigate the effects of nitric oxide(NO) and endothelin-1(ET-1) on the children with Henoch-Schonlein′s purpura(HSP). Methods The plasma NO and ET-1 levels of 48 children with HSP,inclnding 21 children with HSP nephritis (HSPN) and 27 children with non-HSPN (NHSPN), were determined both in acute and recovery phases. Results The concentrations of the plasma NO and ET-1 in acute phase were much higher than those in recovery phase and control group, respectively (P<0.01), and the changes were much more significant in children with HSPN than those without HSPN. The ratio of NO/ET-1 of hypertension group was lower than that of children without hypertension in acute phase (P<0.05). There were no significant differences of the plasma NO and ET-1 between NHSPN group in recovery phase and the control group（P>0.05）. However, the plasma NO and ET-1 concentrations of the HSPN group in recovery phase were still higher than those in the control group (P<0.05),and were lower than acute phase, and the ratio of NO/ET-1 in recovery phase was lower than that in acute phase. There was a positive correlation between NO and ET-1 in children with HSP (HSPN group in acute phase：r=0.7843，P<0.01,in recovery phase：r=0.4920，P<0.01)；NHSPN group in acute phase r=0.6831，P<0.01，in recovery phase r=0.0.6317，P<0.01）. Conclusion The levels of NO and ET-1 are important indexes to determine the state of illness, occurrence of complication and prognosis in children with HSP.

Key words: Schoenlein-Henoch, blood, nephritis, blood, Schonlein′s-Henoch purpura nephritis, nitric oxide, blood, endothelin-1, blood