关键词: 寰枢关节, 异常, 痴呆

Abstract: Objective To observe the effects of instability of cervical vertebral column on the disturbance of the special memory, intelligence, blood urine in mice. Methods 300 mice of 6-month-old were divided equally into an experimental group and a control group. The experimental mice were injected with 15 μL of 30% lactic acid (once every week, 3 weeks continued) in the 1st and 2nd cervical articulation. The control mice were injected with 15 μL of 30% lactic acid (once every week, 3 weeks continued) in the subcuteous tissue which was in the area at upper the gluteobiceps muscle. The memory and intelligence of mice were examined with the conditional avoidance test, float harbor test and white paper test. Results The experimental mice showed special memory and intelligence deficiencies (P<0.01) and the decay of health, change of hematopoietic function and positve urinary protein (P<0.01). Conclusion Instability of cervical vertebral column has correlation with dementia, meanwhile,the stimulating degree to organism is bigger.

Key words: atlanto-axial joint, anomalies, dementia