关键词: 脑梗死；对氧磷酶1基因；标签SNP；多态性, 单核苷酸 脑梗死；对氧磷酶1基因；标签SNP；多态性, 单核苷酸

Abstract:

Abstract:Objective To investigate the relationship between PON1 rs2299262 htSNP polymorphism and cerebral infarction in Chinese northern Han population,and to illustrate whether rs2299262 is a genetic marker of large artery atherosclerotic infarction.Methods A case-control study was performed including 529 cerebral infarction patients and 305 normal subjects.In addition,the cerebral infarction patients were sub-grouped into 304 large artery atherosclerotic infarction patients and 225 lacunar infarction patients based on TOAST standard.PON1 rs2299262 genotypes were determined by PCR-RFLP.Results Compared with control group,the rs2299262 T allelic frequency had significant difference in large artery atherosclerotic infarction group(P<0.05).There were no significant differences of the distribution of rs2299262 T allelic frequency between case and control groups （P>0.05）.When they were divided by gender,there was no difference of the distribution of PON1 rs2299262 allelic frequency and genotypic frequency between the subgroups and control group （P>0.05）.Conclusion The patients with PON1 rs2299262 T allele have a higher risk of large artery atherosclerotic infarction than without it.PON1 gene rs2299262 is probably a genetic marker of large artery atherosclerotic infarction with high risk.

Key words: brain infarction； paraoxonase1 gene； tag SNP； polymorphism,single nucleotide