吉林大学学报(医学版)

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转录因子Oct-4和SOX-2在宫颈癌组织中的表达及其意义

张 璐，魏振彤，李佳佳，郭慧宁，张松灵   

  1. 吉林大学第一医院肿瘤妇科，吉林 长春
  • 收稿日期:2013-05-15 发布日期:2013-12-12
  • 通讯作者: 张松灵(Tel：0431-81875331，E-mail：slzhangsl@jlu.edu.cn) E-mail:slzhangsl@jlu.edu.cn
  • 作者简介:孙晓宏（1974-），男，山东省金乡县人，讲师，副主任医师，医学博士， 主要从事胸部肿瘤基础及临床研究。
  • 基金资助:

     国家自然科学基金资助课题（81060172）

Expressions of transcription factor Oct-4 and SOX-2 in cervical cancer tissue and their significances

ZHANG Lu,WEI Zhen-tong,LI Jia-jia,GUO Hui-ning,ZHANG Song-ling   

  1.  Department of Tumor Gynecology,First Hospital,Jilin University,Changchun 130021,China
  • Received:2013-05-15 Published:2013-12-12

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摘要：

目的：研究转录因子Oct-4和SOX-2在宫颈癌及正常宫颈组织中的表达情况，
阐明二者作为宫颈癌干细胞标记物的可能性。方法：采用免疫组织化学SP法检测Oct-4和SOX-2在
52例宫颈癌组织和28例正常宫颈组织中的表达，分析二者在不同类型宫颈癌患者中的表达情况。
结果：Oct-4在宫颈癌组织中表达率(46.1%，24/52）显著高于其在正常组织中的表达率(7.1%，2/28），二者比较差异有统计学意义（P<0.05）；SOX-2
在宫颈癌组织中的表达率(59.6%，31/52）显著高于其在正常组织中的表达率(10.7%，3/28），
二者比较差异有统计学意义（P<0.05)。宫颈癌组织中Oct-4和SOX-2的表达与患者年龄、病
理类型和FIGO分期均无关联性（P>0.05）；与宫颈癌的分化程度有关联，随分化程度的降低，Oct-4和SO
X-2表达水平升高，不同分化程度宫颈癌患者表达频数比较差异均有统计学意义（P<0.05）；宫颈癌组织中Oct-4与SOX-2的表达频数呈正相关关系（r=0.753，P<0.05）。结论：Oct-4和SOX-2在宫颈癌组织中频数较高，且随宫颈癌分化程度降低表达频数升高，提示Oct-4和SOX-2可作为
宫颈癌干细胞的标记物。

关键词: Oct-4, SOX-2, 宫颈癌, 免疫组织化学, 肿瘤干细胞

Abstract:

Objective To investigate the expressions of transcription factor Oct-4
 and SOX-2 in cervical cancer and normal cervix  tissue and to explore the possibility of Oct-4 and SOX-2 as the  stem cell markers of cervical cancer.
Methods The expressions of Oct-4 and SOX-2  in 52 cases of cervical cancer tissue and 28 cases of normal cervix tissue
 were detected by immunohistochemical SP   method.The expressions of Oct-4 and SOX-2 in the patients with cervical canc
er with different types were analyzed.Results The expression of Oct-4 protein in cervical cancer tissue(46.1%,24/5
2) was significantly higher than that in normal cervix tissue(7.1%,2/28)(P<0.05);the expression of SOX-2 protein in cervical  cancer tissue(59.6%,31/5
2) was significantly higher than that in normal cervix tissue(10.7%,3/28)(P<0.05).The expressions of Oct-4 and SOX-2 in cervical cancer tissue  were significantly correlated with the histological grade(P<0.05);but not correlated with the age,pathological type,FIGO stage of the patients(P＞0.05).The expressions of OCt-4 and SOX-2 were increased with the decreasing of the differentiation degree,and there were significant differences of the expression frequencies  of OCt-4 and SOX-2 in the patients with different differentiation degrees(P<0.05).The expression of Oct-4 was positively related to the expression of SOX-2 in cervical cancer tissue(P<0.05).
Conclusion The expression frequencies of Oct-4 and SOX-2 in cervical cancer tissue are increased with the decreasing of differentiantion degree of cervical cancer which indicates that Oct-4 and SOX-2 may be used as the markers of cervical cancer stem cells.

Key words: Oct-4, SOX-2, cervical cancer, immunohistochemical, cancer stem cell ,  

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