关键词: 性激素结合球蛋白, 胰岛素抵抗

Abstract: Objective To explore the association between sex hormone binding globulin(SHBG) in first trimester of pregnancy and subsequent development of gestational diabetes mellitus (GDM) .Methods During pregnancy, 41 patients with GDM diagnosed with glucose screening and glucose tolerance test were used as GDM group, 734 cases of pregnant women without GDM were used as control group, and the expression levels of SHBG, T, E₂ in two groups were compared. Logistic regression analysis was adopted to analyse the risk factors for GDM. Results ①The level of SHBG in GDM group (269.55 nmol•L^-1±119.35 nmol•L^-1) in first trimester of pregnancy was lower than that in control group (321.77 nmol•L^-1±124.21 nmol•L^-1) (P<0.05). ②Logistic regression analysis result showed there was independent association between SHBG level and GDM （β=0.622,P=0.025,OR=1.864,95%CI 1.083－3.207).③With the decrease of SHBG level ,the morbidity of GDM increased. Conclusion First-trimester SHBG level has independent association with subsequent GDM ,SHBG offers a potential early marker to target women who are at risk for GDM.

Key words: sex hormone binding globulin, insulin resistance