关键词: 癫痫, 脑电描记术, 大鼠, Wistar, 痉挛, 婴儿

Abstract: Objective To explore the possibility of establishment of the animal model of West syndrome. Methods Experiment was performed on 12-day-old Wistar strains (n=64). 32 among them were randomly divided into N-methyl-D- Aspartate (NMDA) treated group（n=16）and control group（n=16）, and had an intraperitoneal injection of NMDA or NS respectively for 14 d in succession. The behavioral manifestations and/or the seizures induced by NMDA in each group were observed and the incidence, latencies, pattern of motor seizures were noted. The changes of ECoG were observed in the rest of Wistar strains (n=32) which were divided into NMDA treated group (n=16) and control group（n=16）. Results The control group had no seizures. NMDA-induced automatisms and emprosthotonus in (12-13)-day-old rats were elicited while automatisms were only elicited by NMDA from 14-day-old rats to 25-day-old rats without emprosthotonus. There were no obvious epileptiform discharge in control rats compared with the NMDA-treated rats which had the characteristic changes of shape waves and spike waves concurrently during automatisms and emprosthonotonic seizures. Conclusion Although the unique seizures with age-specificity induced by NMDA in developing rats can not fulfills all criteria of the West syndrome model, it partially resembles West syndrome in childhood on the aspects of behavioral manifestations and ECoG changes.

Key words: epilepsy, electroencephalography, rats, Wistar, spasms, infantile