关键词: 柯萨奇病毒感染, 心肌炎, 活性氧

Abstract: Objective To observe the effects of Astragalus Membranaceus injection(AMI) on coxsackievirus B₃ (CVB₃) murine viral myocarditis.Methods 70 BALB/C mice were divided randomly into control group,model group,AMI 90,60,18 g·kg^-1 groups (high,middle,low dose groups) and positive group. Viral myocarditis models induced by intraperitoneal inoculation with CVB₃ solution were developed and were treated by high,middle,low doses of AMI respectively. Nine days after administration,the survival rates and the levels of serum AST,LDH,SOD and MDA,the changes in ECG and myocardial tissues were observed. Results The survival rate of the mice was increased and the incidence of abnormal ECG at acute stage was significantly reduced when AMI was used, compared with normal group (P<0.05,P<0.01). The levels of serum AST,LDH,MDA were significantly decreased in AMI treated group,and the activities of SOD were increased especially in middle and low doses of AMI groups (P<0.05,P<0.01).AMI reduced obviously the degreee of lesion in mice with myocarditis. Conclusion AMI exert antagonistic effects on CVB₃ murine myocarditis.

Key words: coxsackievirus infections, myocarditis, reactive oxygen species