Abstract:

Objective To investigate the risk factors for progression of cervical intraepithelial neoplasia Ⅰ （CIN Ⅰ） patients， and to provide more appropriate treatment plans for the CINⅠ patients. Methods The clinical data of 210 patients with CINⅠ confirmed by initial cervical pathological biopsy and conservative treatment were retrospectively analyzed.All the patients were followed up for 24 months to observe the disease progression. Univariate analysis and multivariate Logistic stepwise regression anslysis were used to analyze the influence of patients’ age， human papillomavirus （HPV），liquid based thin layer cytology （TCT）， menopausal status，and transformation zone （TZ）types and image features under colposcope（abnormal vessels，hyperplasia，lesion area， and lesion boundary） on disease progression of the CINⅠ patient at the time of initial diagnosis of CINI disease. Results A total of 40 patients had progressive disease，170 patients had no progressive disease.The univariate analysis results showed that there were statistically significant differences in age （χ²=25.94，P<0.01），TCT stuation （χ²=10.97，P<0.01）， HPV（16/18） infection or not （χ²=4.10，P=0.043）， hyperplasia（χ²=8.18， P=0.004） and menopause status（χ²=25.56， P<0.01）of the pateints between two groups.The multivariate Logistic stepwise regression analysis results showed that age≥45 years old（OR=5.95，P=0.005，95%CI：1.70－20.84），TCT≥ASC-H（OR=3.319，P=0.007，95%CI：1.38－7.97），atypia（OR=9.91，P<0.01，95%CI：2.95－33.34）and hyperplasia （OR=8.51，P<0.01，95%CI：2.60－27.84） were the risk factors for disease progression of the CINⅠ patients. Conclusion Age≥45 years old，TCT≥ASC-H，abnormal blood vessels under colposcope and hyperplasia in the lesion area are the independent risk factors for the disease progression of the CINⅠpatients.

Key words: Cervical intraepithelial neoplasia, Cervical neoplasm, Human papillomavirus, Colposcope, Disease progress