牙釉质白垩斑再矿化治疗药物的研究进展

doi:10.13481/j.1671-587X.20260231

Abstract

Abstract:

White spot lesions （WSLs） represent a change in the optical properties of tooth enamel due to mineral loss， manifesting as a chalky appearance and serving as an early indicator of caries. Remineralization therapy， a non-invasive approach for managing early caries， aims to restore tooth structure and microhardness by inducing mineral deposition through the application of remineralizing agents to remineralize the partially demineralized tooth tissues. Fluoride contributes by forming a protective “fluoride reservoir” and promoting the deposition of fluorapatite； when fluoride is combined with biomaterials or antimicrobial agents， they demonstrate potential to synergistically enhance mineralized restorations while reducing toxicity risks. Biomineralizing substances also show promising applications in inducing enamel repair and maintaining biocompatibility. Additionally， natural ingredients， plant and animal extracts， can effectively synchronize dental hard tissue remineralization with oral microbial control. This review examines various remineralization therapeutic agents， including fluoride， biomineralizing substances， and plant and animal extracts， and elucidates their remineralization mechanisms， application characteristics， interactions， and therapeutic effects. The findings aim to provide a foundation for the remineralization treatment of WSLs.

Key words: White spot lesion, Remineralization, Fluoride, Biomineralization, Plant extract

CLC Number:

R781.2

Boyang GAO, Zunxuan XIE, Jinyao LIU, Jiaming HE, Shunli CHU, Yuyan LIU. Research progress in agents for remineralization of white spot lesions[J].Journal of Jilin University(Medicine Edition), 2026, 52(2): 572-580.

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Research progress in agents for remineralization of white spot lesions

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