Abstract:

Abstract:Objective To investigate the mechanical properties of carbon-fiber-reinforced polyether-ether-ketone(CF/PEEK) composite materials and to evaluate the biocompatibility and bioactivity of CF/PEEK after implanted into mandibula.  Methods 27 adult Japanese white rabbits were randomly divided into experimental group (n=9) and control group (n=18),CF/PEEK was implanted into bilateral mandibula of the rabbits in experimental group,autologous bone was implanted into left mandibula of the rabbits in  positive control group(n=9) while the right sides were taken as blank control group(n=9) without implants.The materials-bone interface of samples were collected to make the observation of gross， imaging and histology and to analyze the  histological score after 8,12,and 16 weeks. Results All the animals and  no infection  had secondary fractures.Obviously callus formation was observed on the edge of the defect in both experimental group and positive control group in the imaging observation,while the rabbits in blank control group had  no obvious change. Compared with 8 weeks after operation，the score evaluation of local cellular immune response showed significant decreasing in  12 weeks after operation(P<0.01)，the data was the  minimum in 16 weeks（P<0.05）.At the same time,the score evaluation of local cellular immune response in three groups showed no significant difference (P> 0.05).Trabecular bone and osteoblasts could be observed in the bone defect of both experimental group and positive control group after 16 weeks,and blank control group was filled with fibrous connective tissue.The osteogenesis rates  in experimental group and positive control group were increased with the prolongation of time,and they were better than that in blank control  group(P<0.01). Conclusion CF/PEEK material has good  mechanical property,biocompatibility and bioactivity;and it has light immune response after implantation.

Key words: polyetheretherketone, carbon fiber, biocompatibility, bone defect