结节性硬化症并发重度缺铁性贫血1例报告并文献复习

doi:10.13481/j.1671-587x.20150529

Abstract

Abstract:

Objective To investigate the clinical features,image features, and pathological features of bone marrow of tuberous sclerosis complex (TSC). Methods One TSC patient's imageological examination was taken,and the bone marrow cells were stained by Wright staining,and the associated literatures were reviewed. Results The obvious clinical manifestations such as facial sebaceous gland tumor and unusual characteristic imageological examination were observed.The severe iron deficiency anemia was observed and improved after support treatment. Conclusion As an autosomal dominant disease,TSC can affect several organ systems and cause systemic diseases such as iron-deficiency anemia.

Key words: tuberous sclerosis complex, iron-deficiency anemia, sebaceous gland tumor

CLC Number:

R734.2

ZHANG Xue, SHI Guang, SUN Yan, GU Jiaying, LI Yarong. Tuberous sclerosis complex complicated with severe iron deficiency anemia:A case report and literature review[J].Journal of Jilin University Medicine Edition, 2015, 41(05): 1023-1026.

References

[1] 焦富勇,卫丽,王杰民,等. 小儿结节性硬化症治疗进展 [J].中华实用儿科临床杂志,2014,29(9):310-312.

[2] Roach ES,Gomez MR,Northrup H.Tuberous scleros complex is consensus conference:revised clinical diagnosis criteria [J].Child Neurol,1998,13(12):624-628.

[3] Bissler J,Henske E.Tuberous sclerosis complex:genes,clinical features and therapeutics[M].USA:Wiley-Blackwell,2010.

[4] 孙新芬,闫春林,方丽,等.结节性硬化症67 例临床分析 [J].临床皮肤科杂志,2005,34(2):78-81.

[5] Muzykewicz DA,Black ME,Muse V,et al.Multifocal micronodular pneumocyte hyperplasia:computed tomographic appearance and follow-up in tuberous sclerosis complex [J].J Comput Assist Tomogr,2012,36(5):518-522.

[6] Johnson SR,Cordier JF,Lazor R,et al.European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis [J].Eur Respir J,2010,35(1):14-26.

[7] Cudzilo CJ,Szczesniak RD,Brody AS,et al.Lymphangioleiomyomatosis screening in women with tuberous sclerosis [J].Chest,2013,144(2):578-585.

[8] Adriaensen ME,Schaefer-Prokop CM,Duyndam DA,et al.Radiological evidence of lymphangioleiomyomatosis in female and male patients with tuberous sclerosis complex [J].Clin Radiol,2011,66(7):625-628.

[9] Shepherd CW,Gomez MR,Lie JT,et al.Causes of death in patients with tuberous sclerosis [J].Mayo Clin Proc,1991,66(8):792-796.

[10] Pei Y.Practical genetics for autosomal dominant polycystic kidney disease [J].Nephron Clin Pract,2011,118(1):c19-c30.

[11] Brook-Carter PT,Peral B,Ward CJ,et al.Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease-a contiguous gene syndrome [J].Nat Genet,1994,8(4):328-332.

[12] Morrison P J,O'Neill T,Hardy R,et al.The prevalence of pica in tuberous sclerosis complex [J].Springerplus,2015,4(51):335-337.

[13] Manabu T,Wataru H,HIroo H,et al.Pancytopenia in tuberous sclerosis [J].Med Sci Monit,2001,7(3):444-447.

[14] Raught B,Gingras AC,Sonenberg N.The target of rapamycin (TOR) proteins[J].Proc Natl Acad Sci, 2001, 98(13):7037-7044.

[15] Bissler JJ,McCormack FX,Young LR,et a1.Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis[J].NEJM,2008,358:140-151.

[16] Plas DR,Thomas G.Tubers and tumers:rapamycin therapy for benign and malignant tumors [J].Curr Opin Cell Biol,2009,21(2):230-236.

[17] 翟锋,栾国明,周健,等.手术治疗结节性硬化的疗效观察[J].中华神经外科杂志,2010,26(1):47-50.

[18] 郑平.胼胝体切开术治疗难治性癫痫的临床进展[J].立体定向和功能性神经外科杂志,2008,21(4):253-256.

[19] 郝坤艳,于乐成,高蕾,等.戊型肝炎相关性单纯红细胞再生障碍性贫血1例报告[J].临床肝胆病杂志,2015,31(7):1126-1127.

Tuberous sclerosis complex complicated with severe iron deficiency anemia:A case report and literature review

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10

[1]	Xin LIU,Yuyang ZHANG,Deling ZENG,Xiaoqin LIU,Lu ZHANG,Meiying LI,Hong CHEN,Bangrong CAO,Shiqi MA. Levels of KLRG1 ⁺NK cells in peripheral blood of NSCLC patients and their clinical significances [J]. Journal of Jilin University(Medicine Edition), 2026, 52(3): 746-754.
[2]	Qiaotong REN,Weihua WU,Xingxiang WANG,Shichao WANG,Yipeng CHENG,Chun LI. Effect of interleukin-17 recepter B gene silencing on proliferation, invasion and apoptosis of lung adenocarcinoma A549 cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2026, 52(3): 738-745.
[3]	Yang LI,Shiyang LI,Hongmei ZHANG,Qianqian LIU,Yubing CHEN. Effect of NGFR gene expression differences on promotion of apoptosis of squamous cell carcinoma and adenocarcinoma cells by PD-1 inhibitor-activated T lymphocytes [J]. Journal of Jilin University(Medicine Edition), 2026, 52(3): 680-693.
[4]	Lei TANG,Peinan LIN,Ling ZHANG,Haiyan XU,Fengchun ZHANG. Chemotherapy efficacy and plasma drug concentration changes in patient with limited-stage small cell lung cancer complicated with uremia: A case report and literature review [J]. Journal of Jilin University(Medicine Edition), 2025, 51(6): 1687-1694.
[5]	Xiaoshuang HE,Lina XU,Mei CUI,Yu ZHAO,Bei WANG,Zheng HUANG,Yuchao WANG,Wenyan XIN,Chao WU. Effects of lncRNA DUXAP8 in lung cancer A549 cells-derived exosomes on lung cancer cell growth and its mechnism [J]. Journal of Jilin University(Medicine Edition), 2025, 51(4): 958-967.
[6]	Xingxiang WANG,Ying ZHAO,Qiaotong REN,Hefei WANG,Gang PU,Chun LI. Promotive effect of M2 macrophages on epithelial-mesenchymal transition and cisplatin resistance in non-small cell lung cancer A549 cells by regulating NF-κB signaling pathway [J]. Journal of Jilin University(Medicine Edition), 2025, 51(3): 642-652.
[7]	Yihui WANG,Qing ZHANG,Yingnan LI,Liping YE. Effect of KIAA1522 on proliferation, migration, and invasion of lung cancer cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2025, 51(3): 727-739.
[8]	Congcong BAI,Xianlei ZHOU,Zhi ZHANG,Shuang GAO,Xuemei ZHANG. Expression of CSPG4P12 gene in small cell lung cancer tissue and its effect on behaviors of cell biology [J]. Journal of Jilin University(Medicine Edition), 2025, 51(2): 392-402.
[9]	Bo LIU,Chao SUN,Xu WANG,Kewei MA. Bioinformatics analysis on differentially expressed genes in multiple primary lung cancers based on GEO database [J]. Journal of Jilin University(Medicine Edition), 2025, 51(2): 437-446.
[10]	Xiaoming WANG,Xueye WANG. Invasive adenocarcinoma of lung complicated with metastatic NUT midline carcinoma of mediastinal lymph node： A case report and literature review [J]. Journal of Jilin University(Medicine Edition), 2024, 50(3): 825-830.
[11]	Aihua REN,Yanbo DONG,Runzhi MIAO,Yujiao LYU,Yanfeng LIU. Effect of ganoderic acid A on glycolysis and its key rate-limiting enzymes of non-small cell lung cancer PC9 cells [J]. Journal of Jilin University(Medicine Edition), 2024, 50(3): 682-688.
[12]	Yuan WANG,Zhijuan WANG,Mingshu ZHANG,Yihui WANG,Qing ZHANG,Liping YE. Effects of monocyte chemoattractant protein-1 on invasion and migration of lung cancer A549 and their mechanisms [J]. Journal of Jilin University(Medicine Edition), 2024, 50(3): 666-675.
[13]	Zongjun CHEN,Yahong CHEN,Liyun HUANG,Ziying LIANG. Effects of genomic instability and MYC gene mutation of non-small cell lung cancer A549 cells on resistance of gemcitabine [J]. Journal of Jilin University(Medicine Edition), 2024, 50(2): 355-363.
[14]	Aihua REN,Xinda JU,Aofei LIU,Yongchao LIU,Yanfeng LIU. Effect of ganoderic acid A on proliferation and apoptosis of human non-small cell lung cancer PC-9 cells and its mechanism [J]. Journal of Jilin University(Medicine Edition), 2023, 49(6): 1466-1472.
[15]	Xiaodong GAI,Ying ZHAO,Hefei WANG,Chengyuan HE,Xingxiang WANG,Chun LI. Regulatory effect of FOXP3 on chemosensitivity of non small-cell lung cancer A549 cells to doxorubicin and its mechnism [J]. Journal of Jilin University(Medicine Edition), 2023, 49(5): 1161-1167.