Abstract:

Abstract:Objective To study the effect of Sanshen Weixin Capsula (Sanshen) on cardiac function in rats with heart failure induced by myocardial infarction,and  to provide basis for developing the new drugs to treat heart failure inducedby myocardial infarction. Methods The heart failure model was induced by myocardial infarction in rats with left anterior descending coronary (LAD) occulusion.The Wistar rats with heart failure were divided into four groups after detecting cardiac function by  echocardiography: sham operation group(n=9),heart failure model group(n=8),ramipril group(n=9) andSanshen group(n=9).After 1 week,the rats in sham operation group and model group were treated  with distilled water,and the rats in Ramipril group and Sanshen group were treated with ramipril and Sanshen,respectively.After 5 weeks,the changes of echocardiography and hemodynamics were observed,and the heartorgan index and infarction area were evaluated,and the histomorphogical changes were observed.Results Compared with model group,the left ventricular end-diastolic dimension (LVEDD) and the left ventricular end-systolic dimension (LVESD)in Sanshen group  were decreased significantly(P<0.01)；the left ventricular ejection fraction（LVEF） and the franctional shortening（FS）were increased significantly(P<0.01).Compared with model group,the left ventricular end diastolic pressu(LVEDP) in Sanshen group  was decreased significantly(P<0.05)；the left ventricular systolic pressure（LVSP） and the maximal ventricular pressure rise ratio during systolic period/decrease ratio during diastolic period（±dp/dtmax） were increased significantly (P<0.05 or P<0.01).Compared with model group,the infraction area of left ventricle and heart organ index in Sanshen group were decreased significantly (P<0.05).Compared with model group,the ventricular myocardial cells in Sanshen group arranged in neat rows,the interstitial edema was significantly reduced,the interstitial connective tissue proliferation and inflammatory cell infiltration were decreased,and the myocardial fibers were not significantly enlarged.Conclusion  Sanshen can improve cardiac function in the rats with heart failure induced by myocardial infarction，suggestting that it can be used as a new drug for treatment of heart failure.

Key words: Sanshen Weixin Capsula, heart failure, echocardiography, hemodynamics