Abstract:

Abstract:Objective To establish doxorubicin　(DOX)-induced myocardial injury rat model and to explore the protective effect of the pseudo-ginsenoside GQ (PGQ) on DOX-induced myocardial injury in rats. Methods The  acute myocardial injury  model was established through the femoral vein injection of doxorubicin,and 30 Wistar male rats were randomly divided into  control group(n=5),DOX group(18 mg?kg-1,n=5),DOX+dexrazoxane(DZR) group(180 mg/kg,n=5);DOX+low,medium,high doses of  PGQ groups(3,6,12 mg/kg/d,n=5). The general state,the heart weight/body weight(HW/BW) ratio, the  cardiac function indexes,the levels of  serum troponin(TnI) of the rats in various groups were detected and the  morphological and ultrastructural changes of myocardium tissue of the rats were observed. Results Compared with  control group,the total decline value of BW of the rats in DOX group was significantly increased(P<0.05);HW/BW ratio was  significantly increased(P<0.05); heart rate(HR),left ventricular systolic(LVSP) and ±dp/dtmax were  significantly decreased(P<0.05),and the level of serum TnI was significantly increased(P<0.05).The morphological and ultrastructural injuries of the myocardium tissue were observed. Compared with DOX group,the HR,LVSP,±dp/dtmax  of the rats in DOX+DZR group and DOX+medium dose of PGQ group were significantly increased(P<0.05),and the levels of serum TnI were significantly decreased(P<0.05),and HW/BW ratios were  significantly decreased(P<0.05).The morphological and ultrastructural injuries were significantly improved compared with DOX group. Compared with DOX+DZR group,the total decline value of BW of the  rats in  DOX+medium dose of PGQ group was significantly decreased(P<0.05),and the  ultrastructural injury was significantly improved.Conclusion  PGQ has the protective effect of myocardial injury against DOX-induced myocardial injury.

Key words: pseudo-ginsenoside GQ, doxorubicin, myocardial injury, protective effect