Abstract:

Abstract:Objective
To analysis the clinical distribution and resistance characteristics in isolates of Acinetobacter baumannii(Ab), and provide evidence for clinical prevention and therapy. Methods 1 504 Ab strains were isolated from clinical specimens in Xuanwu Hospital of Beijing Capital Medical Univercity from January, 2006 to October, 2009. The clinical distribution and the resistance results of Ab were analyzed retrospectively. Results The majority of these Ab strains was distributed in ICUs(665 strains, account for 44.2%) and emergency wards(123 strains, account for 8.2%). Other common wards isolated 716 strains(account for 47.6%). The majority of these Ab strains was isolated from sputum(1 304 strains, account for 89.6%). The resistance of Ab showed the rising tendency to all kinds of antibiotics, especially to imipenem. Despite the resistance rate of imipenem acquired 71.8% in 2009, it was the most sensitive drug of treating Ab(the sensitivity was 28%).The resistance rate of cefotaxime(CTX) was 100% in 2006, whose application was decreased in 2007, but decrea
sed to 33.3% in 2008. Multi-drug resistance Ab had been emerged. Conclusion The majority of Ab distributes in ICU.Carbapenems are the most sensitive drugs of treating Ab. If a highly resistant drug is stopped using over a period of time, the sensitivity of  Ab to antibiotic  may be increased.

Key words: Acinetobacter baumannii; , resistance characteristic