Abstract:

Abstract:Objective  To clarify the characteristics of the patients with  ankylosing
 spondylitis (AS) complicated with Sjogren’[KG-*3]s syndrome (SS),and to provide basis for its treatment and prevention of complications.Methods 11 cases  diagnosed as AS complicated with SS were selected,and the clinical features and laboratory fingdings were summarized  retrospectively;the rate of involved joints,HLA-B27 positive rate,antinuclear antibody(ANA)positive rate,and the levels of C-eaction protein(CRP),erythrocyte sedimentation  rate (ESR) and immunoglobulin  were compared  between the patients with AS complicated with SS and  the simple AS or SS patients.Results All the   11 patients were in line with the diagnostic criteria for AS and SS with  low back pain and siccaymptoms;peripheral joints were involved in 9 cases.1 case had uveitis;the imaging studies showed that there were 9 cases of  grade 2 bilateral sacroiliitis and above,and 1 case of grade 3 unilateral sacroiliitis,1 case of grade 4 unilateral sacroiliitis.The HLA-B27 was positive in 7 cases,and the positive rate (63.6%)  was ignificantly lower than thatof simple AS patients(92.9%)(P<0.05). The salivary radionuclide examination was positive in 9 cases;the Schirmer test was positive in 11 cases.Among 11 patients with AS complicated with  SS,9 cases were ANA positive,the ANA positive rates had  no significant difference between  patients with AS complicated with SS(81.8%)  and simple SS patients(84.89%).The  anti-SSA ntibodies were positive in 8 cases;the anti-SSB antibodies  were positive in 6 cases;the minor salivary gland biopsy was positive in 11 cases.The levels of CRP,ESR,and immunoglobulin of the patients with AS complicated with SS were higher than those of AS patients or SS patients,but the differences were not significant(P>0.05).Compared with AS patients,the incidence of hyperglobulinemia in patients with AS complicated with SS was increased(P<0.05).Conclusion AS and SS can occur at the same ime,and the patients with AS complicated with SS are prefer to  peripheral joint involvement.

Key words: ankylosing spondylitis, Sjogren’syndrome, antinuclear antibody, immunoglobulin