A total of 50 rats were randomly divided into sham operation group， model group， hirudin group， atorvastatin group and combination group（n=10）. The rat models with acute myocardial infarction were established by ligating the left anterior descending coronary artery.The rats in hirudin group， atorvastatin group and combination group were given 50 U·kg^－1 hirudin， 10 mg·kg^－1 atorvastatin， 50 U·kg^－1 hirudin and 10 mg·kg^－1 atorvastatin， respectively； while the rats in sham operation group and model group were given normal saline for 4 weeks. The 2，3，5-Triphenyte-trazoliumchloride （TTC） staining method was used to determine the myocardial infarction areas of the rats，and the percentage of myocardial infarction area was calculated. HE staining was used to observe the pathomorphology of myocardium tissue of the rats. Western blotting method was used to detect the protein expression levels of vascular cell adhesion molecule-1（VCAM-1） and intercellular adhesion molecule-1（ICAM-1） proteins in myocardium tissue of the rats. ELISA was used to determine the levels of endothelin-1（ET-1）， von Willebrand factor （vWF）， nitric oxide（NO）， tumor necrosis factor （TNF-α ）and interleukin- 6 （IL-6） in serum of the rats.

Compared with sham operation group， the arrangement of myocardial cells in model group were disordered， some cells were incomplete， myocardial necrosis was serious， and inflammatory cell infiltration was found. Compared with model group，the arrangement of myocardial cells in hirudin group，atorvastatin group and combination group was in order，the myocardial necrosis was improved，and the inflammatory cell infiltraton was alleviated.Compared with sham operation group， the expression levels of VCAM-1 and ICAM-1 proteins in myocardium tissue of the rats in model group were significantly increased （P<0.05）， the levels of ET-1， vWF， TNF-α and IL-6 in serum were significantly increased （P<0.05）， and the level of NO was significantly decreased （P<0.05）. Compared with model group， the percentages of myocardial infarction areas of the rats in hirudin group， atorvastatin group and combination group were significantly reduced （P<0.05）， the expression levels of VCAM-1 and ICAM-1 proteins in myocardium tissue of the rats were significantly decreased （P<0.05），the levels of ET-1， vWF， TNF-α and IL-6 in serum were significantly decreased （P<0.05）， and the levels of NO were significantly increased （P<0.05）. Compared with hirudin group and atorvastatin group， the percentage of myocardial infarction area of the rats in combination group was significantly reduced （P<0.05）， the expression levels of VCAM-1 and ICAM-1 proteins in myocardium tissue of the rats were significantly decreased （P<0.05），the levels of ET-1， vWF， TNF-α and IL-6 in serum were significantly decreased （P<0.05）， and the level of NO was significantly increased （P<0.05）.

Hirudin and atorvastatin can protect the vascular endothelium injury， and its mechanism may be related to regulating the secretion of active substances， inhibiting inflammation and reducing cell adhesion；combined therapy is more effective than hirudin or atorvastatin used alone.