A total of 51 patients underwent coronary artery bypass grafting under cardiopulmonary bypass in our hospital were selected， including 30 patients received Del Nido cardioplegia （DN group） and 21 patients received blood containing cardioplegia （hemoperfusion group）.The intraoperative aortic cross-clamp （ACC） time， cardiopulmonary bypass （CPB） time， the number and total amount of pleural fluid perfusion， automatic repulse， introoperative blood loss，blood biochemical index，operation time， postoperative mechanical ventilation time and other indicators of the patients in two groups were collected， and the postoperative complications such as atrial fibrillation， myocardial infarction and retrosternal infection of the patients in two groups were observed.

There were no statistical differences in radix data of the patients between DN group and hemoperfusion group （P>0.05）. Compared with hemoperfusion group，the number and volume of intraoperative cardioplegia and intraoperative blood transfusion demand of the patients in DN group were significantly decreased （P<0.01）， and the rate of automatic resuscitation was increased（P<0.01）. There were no significant differences in potassium ion， blood glucose， hemoglobin， lactic acid level， hematocrit， postoperative mechanical ventilation time， time of ICU stay， postoperative creatinine level and postoperative complications of the patients between two groups before and after transfer （P>0.05）.

Del Nido cardioplegia is safe and effective in coronary artery bypass grafting， and has a clear myocardial protection effect. In addition， compared with conventional blood-containing cardioplegia， Del Nido cardioplegia can reduce the total amount and times of cardioplegia， have a higher repulse rate， and reduce the amount of perioperative blood transfusion.