基底膜成分和结构对上皮细胞极化的作用及其机制研究进展

doi:10.13481/j.1671-587X.20240133

Abstract

Abstract:

The basement membrane is a specialized extracellular matrix between the epithelium and the mesenchyme. In stratified epithelium, only the basal cells in contact with the basement membrane exhibit the apical-basal polarity, whereas the epithelial cells do being not in contact with the basement membrane do not exhibit the apical-basal polarity. The basement membrane plays an important role in epithelial cell polarization. It is an important extracellular matrix (ECM) structure in the multicellular organisms, is situated between the epithelium and the mesenchyme, and is produced jointly by the epithelial cells and mesenchymal cells. Its components mainly include Laminin, type Ⅳ collagen (Col-Ⅳ), nidogen(NDG), and heparan sulfate proteoglycans (HSPG), and each component plays the different role in influencing the epithelial cell polarity. The network scaffold formed by Col-Ⅳ and Laminin is the main structure of the basement membrane, and the integrity of the structure affects the epithelial cell polarization. This review summarizes the composition and structure of the basement membrane, focuses on its role in epithelial cell polarization and its mechanism, and compiles the current status of biomimetic basement membrane materials that promotes the epithelial cell polarization, and provides the theoretical foundation for further exploration of the establishment and maintenance of epithelial cell polarity.

Key words: Basement membrane, Epithelial cell polarity, Apical-basal polarity, Laminin, Mesenchymal cell

CLC Number:

Xueying BAI,Xiaoling WANG,Jinbiao QIANG,Xinyi FAN,Ce SHI. Research progress in role of composition and structure of basement membrane in epithelial cell polarization and its mechanism[J].Journal of Jilin University(Medicine Edition), 2024, 50(1): 265-272.

References 49

1	BUCKLEY C E， JOHNSTON DST. Apical-basal polarity and the control of epithelial form and function［J］. Nat Rev Mol Cell Biol， 2022， 23（8）： 559-577.
2	TENTAKU A， KURISU S， SEJIMA K， et al. Proximal deposition of collagen Ⅳ by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro［J］. FEBS J， 2022， 289（23）： 7466-7485.
3	WALMA D A C， YAMADA K M. The extracellular matrix in development［J］.Development，2020，147（10）： dev175596.
4	JANDL K， MUTGAN A C， ELLER K， et al. The basement membrane in the cross-roads between the lung and kidney［J］. Matrix Biol， 2022， 105： 31-52.
5	JAIN P， RAUER S B， MÖLLER M， et al. Mimicking the natural basement membrane for advanced tissue engineering［J］. Biomacromolecules， 2022，23（8）： 3081-3103.
6	KEELEY D P， HASTIE E， JAYADEV R， et al. Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding［J］. Dev Cell，2020，54（1）： 60-74.
7	KLUßMANN-FRICKE B J， MARTÍN-BERMUDO M D， LLIMARGAS M. The basement membrane controls size and integrity of the Drosophila tracheal tubes［J］. Cell Rep， 2022， 39（4）： 110734.
8	KLEIN G， LANGEGGER M， TIMPL R，et al. Role Laminin A chain in the development of epithelial cell polarity［J］. Cell，1988，55： 331-341.
9	LÁZARO-DIÉGUEZ F， COHEN D， FERNANDEZ D，et al. Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes［J］. J Cell Biol， 2013， 203（2）： 251-264.
10	RASMUSSEN J P， REDDY S S， PRIESS J R. Laminin is required to orient epithelial polarity in the C. elegans pharynx［J］. Development， 2012， 139（11）： 2050-2060.
11	LIU L X， SUN Q Z， DAVIS F， et al. Epithelial-mesenchymal transition in organ fibrosis development： current understanding and treatment strategies［J］. Burns Trauma， 2022， 10： tkac011.
12	WANG Y， LI S L， ZHAO J， et al. Snail-mediated partial epithelial mesenchymal transition augments the differentiation of local lung myofibroblast［J］. Chemosphere， 2021， 267： 128870.
13	DRAKE J M， BARNES J M， MADSEN J M， et al. ZEB1 coordinately regulates laminin-332 and beta 4 integrin expression altering the invasive phenotype of prostate cancer cells［J］. J Biol Chem， 2010， 285（44）： 33940-33948.
14	HUANG C Q， CHEN J. Laminin‑332 mediates proliferation， apoptosis， invasion， migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma［J］. Mol Med Rep， 2021， 23（1）： 11.
15	WANG H， CAI J， DU S X， et al. LAMC2 modulates the acidity of microenvironments to promote invasion and migration of pancreatic cancer cells via regulating AKT-dependent NHE1 activity［J］.Exp Cell Res，2020，391（1）： 111984.
16	MAL’TSEVA D V， MAKAROVA Y A， RAIGORODSKAYA M P， et al. Effects of laminins 332 and 411 on the epithelial-mesenchymal status of colorectal cancer cells［J］. Bull Exp Biol Med， 2019， 166（3）： 377-382.
17	MALTSEVA D V， MAKAROVA J A， KHRISTICHENKO A Y， et al. Epithelial to mesenchymal transition marker in 2D and 3D colon cancer cell cultures in the presence of laminin 332 and 411［J］. Mol Biol， 2019， 53（2）： 330-338.
18	BAO Z， ZENG W， ZHANG D， et al. SNAIL induces EMT and lung metastasis of tumours secreting CXCL2 to promote the invasion of M2-type immunosuppressed macrophages in colorectal cancer［J］. Int J Biol Sci， 2022， 18（7）： 2867-2881.
19	SUN D S， LI F J， LIU L， et al. PSMA3-AS1 induced by transcription factor PAX5 promotes cholangiocarcinoma proliferation， migration and invasion by sponging miR-376a-3p to up-regulate LAMC1［J］. Aging， 2022， 14（1）： 509-525.
20	QUINLAN C， RHEAULT M N. Genetic basis of type Ⅳ collagen disorders of the kidney［J］. Clin J Am Soc Nephrol， 2021， 16（7）： 1101-1109.
21	KASHTAN C E， DING J， GAROSI G， et al. Alport syndrome： a unified classification of genetic disorders of collagen Ⅳ α345： a position paper of the Alport Syndrome Classification Working Group［J］. Kidney Int， 2018， 93（5）： 1045-1051.
22	ADELFIO M， SZYMKOWIAK S， KAPLAN D L. Matrigel-free laminin-entactin matrix to induce human renal proximal tubule structure formation in vitro ［J］. ACS Biomater Sci Eng， 2020， 6（12）： 6618-6625.
23	QURESHI O S， BON H， TWOMEY B， et al. An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable， fibrillar extracellular matrix［J］. Biol Open， 2017， 6（10）： 1423-1433.
24	CUI X J， SHAN T， QIAO L N.Collagen type Ⅳ alpha 1 （COL4A1） silence hampers the invasion， migration and epithelial-mesenchymal transition （EMT） of gastric cancer cells through blocking Hedgehog signaling pathway［J］. Bioengineered， 2022， 13（4）： 8972-8981.
25	SCHNEIDER M， KHALIL A A， POULTON J， et al. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization［J］. Development， 2006， 133（19）： 3805-3815.
26	LIN Q， LONG C L， WANG Z G， et al. Hirudin， a thrombin inhibitor， attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling［J］.Exp Ther Med，2022，23（1）： 3.
27	WOLFSTETTER G， DAHLITZ I， PFEIFER K，et al. Characterization of drosophila nidogen/entactin reveals roles in basement membrane stability， barrier function and nervous system patterning［J］. Development， 2019， 146（2）： dev168948.
28	HAN N N， LI X， WANG Y P， et al. HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma［J］. Oral Oncol， 2022， 131： 105940.
29	XU X H， ZHOU X Y， GAO C， et al. Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p［J］. Aging， 2020， 12（9）： 7774-7785.
30	ROKAVEC M， BOUZNAD N， HERMEKING H. Paracrine induction of epithelial-mesenchymal transition between colorectal cancer cells and its suppression by a p53/miR-192/215/NID1 axis［J］. Cell Mol Gastroenterol Hepatol， 2019， 7（4）： 783-802.
31	FERRARO D A， PATELLA F， ZANIVAN S， et al. Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells［J］.BMC Cancer，2019，19（1）： 312.
32	WANG G， LE Y， WEI L P， et al. CREB3 transactivates lncRNA ZFAS1 to promote papillary thyroid carcinoma metastasis by modulating miR-373-3p/MMP3 regulatory axis［J］. Int J Endocrinol， 2021， 2021： 9981683.
33	YANG G Y， ZHANG C J. CTBP1-AS2 promoted non-small cell lung cancer progression via sponging the miR-623/MMP3 axis［J］. Environ Sci Pollut Res Int， 2022， 29（25）： 38385-38394.
34	ZHANG H H， LI R， LI Y J， et al. eIF4E‑related miR‑320a and miR‑340‑5p inhibit endometrial carcinoma cell metastatic capability by preventing TGF‑β1‑induced epithelial‑mesenchymal transition［J］. Oncol Rep， 2020， 43（2）： 447-460.
35	ZHANG Y B， MO Y Q， YUAN J L， et al. MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells［J］. Nanotoxicology， 2021，15（10）： 1380-1402.
36	LIU Z X， JIN H， YANG S， et al. SDC1 knockdown induces epithelial-mesenchymal transition and invasion of gallbladder cancer cells via the ERK/Snail pathway［J］. J Int Med Res， 2020， 48（8）： 300060520947883.
37	FUJII T， SHIMADA K， TATSUMI Y， et al. Syndecan-1 up-regulates microRNA-331-3p and mediates epithelial-to-mesenchymal transition in prostate cancer［J］. Mol Carcinog， 2016， 55（9）： 1378-1386.
38	COHEN D， FERNANDEZ D， LÁZARO-DIÉGUEZ F，et al. The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling［J］. J Cell Biol， 2011， 192（3）： 525-540.
39	LEWANDOWSKI K T， PIWNICA-WORMS H. Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity［J］. J Cell Sci， 2014， 127（Pt 2）： 315-327.
40	MATLIN K S， MYLLYMÄKI S M， MANNINEN A. Laminins in epithelial cell polarization： old questions in search of new answers［J］. Cold Spring Harb Perspect Biol， 2017， 9（10）： a027920.
41	DOGTEROM M， KOENDERINK G H. Actin-microtubule crosstalk in cell biology［J］. Nat Rev Mol Cell Biol， 2019， 20（1）： 38-54.
42	LI S H， QI Y M， MCKEE K， et al. Integrin and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization［J］. Matrix Biol， 2017， 57/58： 272-284.
43	VONG K I， MA T C， LI B Y， et al. SOX9-COL9A3-dependent regulation of choroid plexus epithelial polarity governs blood-cerebrospinal fluid barrier integrity［J］. Proc Natl Acad Sci U S A， 2021，118（6）： e2009568118.
44	AISENBREY E A， MURPHY W L. Synthetic alternatives to matrigel［J］. Nat Rev Mater， 2020，5（7）： 539-551.
45	ORKIN R W， GEHRON P， MCGOODWIN E B，et al. A murine tumor producing a matrix of basement membrane［J］. J Exp Med， 1977， 145（1）： 204-220.
46	BAKHTI M， SCHEIBNER K， TRITSCHLER S，et al. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro ［J］. Mol Metab， 2019， 30： 16-29.
47	KENT A J， MAYER N， INMAN J L， et al. The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins［J］. Biomaterials， 2019， 218： 119337.
48	ROFAANI E， PENG J， WANG L， et al. Fabrication of ultrathin artificial basement membrane for epithelial cell culture［J］. Microelectron Eng， 2020， 232： 111407.
49	WILSON R L， SWAMINATHAN G， ETTAYEBI K， et al. Protein-functionalized poly（ethylene glycol） hydrogels as scaffolds for monolayer organoid culture［J］. Tissue Eng Part C Methods， 2021， 27（1）： 12-23.

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Research progress in role of composition and structure of basement membrane in epithelial cell polarization and its mechanism

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