塑化剂DEHP暴露人群血清甲状腺激素水平变化的Meta分析

doi:10.13481/j.1671-587x.20170114

Abstract

Abstract:

Objective: To systematically evaluate the changes of serum thyroid hormone levels in di-2-ethylhexyl phthalate (DEHP) exposure population,and to provide a scientific evidence for the study on pathogenesis of thyroid disease.Methods: The studies about the association between DEHP exposure and thyroid hormone levels published with Chinese and English were electronically searched in PubMed,EMbase,CNKI database,WanFang database and VIP Chinese Journal Database up to July 1,2016. According to the inclusion and exclusion criteria,the data was extracted and screened by two researchers.The results of Meta-analysis were performed using RevMan 5.2 software.Results: Seven studies were finally screened,including one high-quality and six medium-quality studies.All studies were published with English,involving 5 692 samples.The results of Meta-analysis showed that the levels of serum TSH,FT4 and T4 were reduced respectively by 10% (OR=0.10,95%CI:0.02-0.44,P=0.002),6% (OR=0.06,95%CI,0.00-0.81, P=0.03),and 7% (OR=0.07,95%CI:0.01-0.39,P=0.002),with the increasing of urine mono-2-ethylhexyl phthalate (MEHP) level with 1 μg·L^-1, whereas the relation between DEHP and T3 had no statistical significance (P=0.11).Conclusion: Human DEHP exposure can reduce the levels of thyroid hormones in different degrees.

Key words: Meta-analysis, thyroid hormones, di-2-ethylhexyl phthalate, human exposure

CLC Number:

SUN Di, WANG Qi, CHEN Haiji, XU Feng, ZHANG Yuezhu, ZHANG Tianrong, LIU Hongbo, YE Lin. Changes of serum thyroid hormone levels in DEHP exposure population: A Meta-analysis[J].Journal of Jilin University Medicine Edition, 2017, 43(01): 66-72.

References

[1] Testai E,Hartemann P,Rastogi SC,et al.The safety of medical devices containing DEHP plasticized PVC or other plasticizers on neonates and other groups possibly at risk (2015 update)[J].Regul Toxicol Pharmacol,2016,76(4):209-210.
[2] Al-Natsheh M,Alawi M,Fayyad M,et al.Simultaneous GC-MS determination of eight phthalates in total and migrated portions of plasticized polymeric toys and childcare articles[J].J Chromatogr B Analyt Technol Biomed Life Sci,2015,985:103-109.
[3] Al-Saleh I,Elkhatib R.Screening of phthalate esters in 47 branded perfumes[J].Environ Sci Pollut Res Int,2016,23(1):455-468.
[4] Wang J,Chen G,Christie P,et al.Occurrence and risk assessment of phthalate esters (PAEs) in vegetables and soils of suburban plastic film greenhouses[J].Sci Total Environ,2015,523(8):129-137.
[5] Schettler T.Human exposure to phthalates via consumer products[J].Int J Androl,2006,29(1):134-139.
[6] Liu T,Li N,Zhu J,et al.Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats[J].Reprod Toxicol,2014,46:141-147.
[7] Martins K,Applegate B,Hagedorn B,et al.Di(2-ethylhexyl) phthalate inhibits B cell proliferation and reduces the abundance of IgM-secreting cells in cultured immune tissues of the rainbow trout[J].Fish Shellfish Immunol,2015,44(1):332-341.
[8] Lo D,Wang YT,Wu MC.Hepatoprotective effect of silymarin on di(2-ethylhexyl)phthalate (DEHP) induced injury in liver FL83B cells[J].Environ Toxicol Pharmacol,2014,38(1):112-118.
[9] Wang WL,Wu QY,Wang C,et al.Health risk assessment of phthalate esters (PAEs) in drinking water sources of China[J].Environ Sci Pollut Res Int,2015,22(5):3620-3630.
[10] Jia X,Harada Y,Tagawa M,et al.Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate:a cross-sectional study[J].Environ Health Prev Med,2015,20(3):168-178.
[11] Rajesh P,Balasubramanian K.Di(2-ethylhexyl)phthalate exposure impairs insulin receptor and glucose transporter 4 gene expression in L6 myotubes[J].Hum Exp Toxicol,2014,33(7):685-700.
[12] Meeker JD,Calafat AM,Hauser R.Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men[J].Environ Health Perspect,2007,115(7):1029-1034.
[13] Huang PC,Kuo PL,Guo YL,et al.Associations between urinary phthalate monoesters and thyroid hormones in pregnant women[J].Hum Reprod,2007,22(10):2715-2722.
[14] Boas M,Hegedüs L,Feldt-Rasmussen U,et al.Association of thyroid gland volume,serum insulin-like growth factor-I,and anthropometric variables in euthyroid prepubertal children[J].J Clin Endocrinol Metab,2009,94(10):4031-4035.
[15] Tsai HJ,Wu CF,Tsai YC,et al.Intake of Phthalate-tainted Foods and Serum Thyroid Hormones in Taiwanese Children and Adolescents[J].Sci Rep,2016,6:30589.
[16] Johns LE,Ferguson KK,McElrath TF,et al.Associations between repeated measures of maternal urinary phthalate metabolites and thyroid hormone parameters during pregnancy[J].Environ Health Perspect,2016,124(11):1808-1815.
[17] Wells GA,Shea BJ,O' Connell D,et al.The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in Meta-analysis[OL].http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.
[18] Minatoya M,Naka Jima S,Sasaki S,et al.Effects of prenatal phthalate exposure on thyroid hormone levels,mental and psychomotor development of infants:The Hokkaido Study on Environment and Children's Health[J].Sci Total Environ,2016,565:1037-1043.
[19] Yao HY,Han Y,Gao H,et al.Maternal phthalate exposure during the first trimester and serum thyroid hormones in pregnant women and their newborns[J].Chemosphere,2016,157:42-48.
[20] Johns LE,Ferguson KK,Soldin OP,et al.Urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels during pregnancy:a longitudinal analysis[J].Reprod Biol Endocrinol,2015,13:4.
[21] Meeker JD,Ferguson KK.Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S.adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008[J].Environ Health Perspect,2011,119(10):1396-1402.
[22] Larsen PR.Decade in review-thyroid disease:The endocrinology of thyroid disease from 2005 to 2015[J].Nat Rev Endocrinol,2015,11(11):634-636.
[23] Chen W,Zheng R,Zuo T,et al.National cancer incidence and mortality in China,2012[J].Chin J Cancer Res,2016,28(1):1-11.
[24] Zhai W,Huang Z,Chen L,et al.Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP)[J].PLoS One,2014,9(3):e92465.
[25] Liu C,Zhao L,Wei L,et al.DEHP reduces thyroid hormones via interacting with hormone synthesis-related proteins,deiodinases,transthyretin,receptors,and hepatic enzymes in rats[J].Environ Sci Pollut Res Int,2015,22(16):12711-12719.
[26] Casas L,Fernández MF,Llop S,et al.Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children[J].Environ Int,2011,37(5):858-866.
[27] Shen O,Du G,Sun H,et al.Comparison of in vitro hormone activities of selected phthalates using reporter gene assays[J].Toxicol Lett,2009,191(1):9-14.
[28] Wenzel A,Franz C,Breous E,et al.Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells[J].Mol Cell Endocrinol,2005,244(1/2):63-71.
[29] Erkekoglu P,Giray BK,Kizilgun M,et al.Thyroidal effects of di-(2-ethylhexyl) phthalate in rats of different selenium status[J].J Environ Pathol Toxicol Oncol,2012,31(2):143-153.
[30] 李庆,刘婵,夏佳佳,等.成人生长激素缺乏症患者内脏脂肪指数与心血管疾病风险因素的相关性研究[J].解放军医学杂志,2016,41(10):842-846.
[31] 田园如画,周中和,陈会生.腺苷酸活化蛋白激酶在缺血预处理诱导的神经保护的作用[J].解放军医学杂志,2015,40(5):366-371.

Changes of serum thyroid hormone levels in DEHP exposure population: A Meta-analysis

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