Abstract:

Objective To identify the diagnosis value of ^99mTcO^－₄/^99mTc-MIBI combined with imaging in thyroid carcinoma by comparing the diagnostic results of ^99mTcO^－₄/^99mTc-MIBI combined with imaging and neck color Doppler ultrasonography (CDU) in thyroid carcinoma,postoperative recurrence or cervical part metastasis. Methods 150 patients with thyroid carcinoma treated by operation and 21 patients who were carried out the second operation because of the suspicion of postoperative recurrence or cervical part metastasis were selected. The pathological results were used as the gold standard and  the diagnostic values of ^99mTcO^－₄/^99mTc-MIBI  combined with imaging and neck CDU in analyzing 437 cases of thyroid carcinoma，215 cases of thyroid carcinoma which diameter was greater than 1 cm and 87 cases of suspected postoperative recurrence or cervical part metastasis were compared respectively. Results In the diagnosis of thyroid carcinoma,the sensitivity of CDU(89.10%) was higher than that of ^99mTcO^－₄/^99mTc-MIBI combined with imaging (81.99%);the patho-coincidences of CDU and ^99mTcO^－₄/^99mTc-MIBI combined with imaging were 84.67% and 80.78%, respectively,there was no significant difference（P>0.05).In the diagnosis of thyroid carcinoma which diameter was great
er than 1 cm,the sensitivity of ^99mTcO^－₄/^99mTc-MIBI combined with imaging（97.75%）was higher than that of CDU（89.89%）；the patho-coincidences of CDU and ^99mTcO^－₄/^99mTc-MIBI combined with imaging were 84.65% and 87.44%,respectively,there was no significant difference（P>0.05）.In the diagnosis of suspected postoperative recurrence or cervical part metastasis,the sensitivity and specificity of CDU（44.78%,40.00%）were lower than those of  ^99mTcO^－₄/^99mTc-MIBI combined with imaging（64.18%,80.00%）,the patho-coincidences of CDU and ^99mTcO^－₄/^99mTc-MIBI combined with imaging were 43.68% and 67.82%，respectively,there was significant difference（P<0.05）. Conclusion ^99mTcO^－₄/^99mTc-MIBI combined with imaging is more sensitive in large diameter thyroid carcinoma,especially has obvious advantage in diagnosing postoperative recurrence or cervical part metastasis.

Key words: thyroid neoplasms, radionuclide imaging, Tc, sestamibi