Abstract:

Objective To investigate the coronary artery calcium scores of subjects with different 25(OH)D levels and to clarify the relationship between 25(OH)D level and coronary artery calcification.Methods A total of 184 subjects were
evaluated by multi-slice spiral CT coronary artery calcium imaging and 25(OH)D levels testing.The subjects were divided into two groups according to 25(OH)D level: 25(OH)D deficient group(＜15 μg?L-1) and 25(OH)D  normal  group≥(15 μg?L-1). The average coronary artery calcium scores of the two groups were compared and the relationship between coronary artery calcium scores and 25(OH)D levels of all 184 subjects was analyzed.
Results There were 120 subjects in normal group, whose average coronary artery calcium score was 43.9±91.7, and 55 subjects out of  the group (45.8%) scored zero.The 25(OH)D deficient group had 64 subjects, whose
 average coronary artery calcium score was 200.0±113.5, and 21 out of the group (32.8%) scored zero.The average coronary artery calcium score in normal group was much lower than that in deficient group, and the number of zero-score subjects in normal group was also more than that in deficient group; the differences between two groups were statistically significant(P<0.05).There was negative relationship between coronary artery calcium scores and 25(OH)D levels (r=－0.147, P<0.05).Conclusion The 25(OH)D level is negatively correl
ated to coronary artery calcium score.The deficiency of 25(OH)D  can cause coronary artery calcification.
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Key words: 25-hydroxyvitamin D, coronary artery, calcification